RNA from Borna disease virus in patients with schizophrenia, schizoaffective patients, and in their biological relatives

Nunes, Sandra; Itano, Eiko Nakagawa; Amarante, Marla Karine; Reiche, Edna Maria Vissoci; Miranda, Helen Cristina; Oliveira, Carlos Eduardo Coral de; Matsuo, Tiemi; Vargas, Heber Odebrechet; Watanabe, Maria Angélica Ehara

doi:10.1002/jcla.20261

Cited by 28 publications

(19 citation statements)

References 51 publications

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“…The detection of BDV‐RNA in peripheral blood of psychiatric patients and their relatives using ultrasensitive reverse transcription–polymerase chain reaction 9–11 further supported this hypothesis, although sequence similarities between human BDV strains and laboratory strains highlighted the possibility of false‐positive results due to contaminations, 12,13 and the importance of rigorous safety conditions. A triple enzyme‐linked immunosorbent assay (ELISA) developed by Bode et al.…”

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confidence: 52%

Anti‐Borna disease virus antibody responses in psychiatric patients: Long‐term follow up

Heinrich

Adamaszek

2010

Psychiatry Clin Neurosci

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Aim: Data suggesting a pathogenetic role for Borna disease virus (BDV) in neuropsychiatric diseases are still inconclusive and it is unknown whether humans become persistently infected or clear the virus infection. The aim of the present study was therefore to investigate long-term BDV-specific antibody responses in psychiatric patients in order to gain new insights into human BDV infection and its pathogenicity.Methods: BDV-specific antibody titers and associations with clinical conditions were studied retrospectively in 94 seropositive patients with schizophrenia (n = 46), affective disorders (n = 19) and other psychiatric disorders (n = 29) who had been repeatedly tested for the presence of BDV-specific antibodies on indirect immunofluorescence assay between 1985 and 2006. Long-term titer dynamics were studied in 46 patients followed up for a period of >36 months.Results: A total of 25 of these 46 patients (54.3%) had persistent seropositivity, whereas seroreversion from positive to negative was observed in 21 (45.7%). Patients in the early course of schizophrenia had lower antibody titers compared to patients in the advanced course (P = 0.017), while a higher proportion of patients in the early course had titer increases (P < 0.05). There were no significant differences in antibody titers between patient subgroups with clinically stable and acute psychiatric disorders.Conclusion: Persistent seropositivity in a subgroup of psychiatric patients in the long-term analysis suggests chronic BDV infection in humans.

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confidence: 52%

Anti‐Borna disease virus antibody responses in psychiatric patients: Long‐term follow up

Heinrich

Adamaszek

2010

Psychiatry Clin Neurosci

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“…It has been reported that BDV is not associated with psychiatric patients in Kyushu island in Japan, a known endemic area of BDV infection 8,42,49. However, there have been two BDV-positive reports in Brazil, which has not been known to be an endemic BDV infection area 23,24. Third, the pathogenesis and symptoms of BDV infection in humans would be different from the infection in animals.…”

Section: Discussionmentioning

confidence: 95%

Failure to Detect Borna Disease Virus Antibody and RNA from Peripheral Blood Mononuclear Cells of Psychiatric Patients

Lee

Tae

Song

et al. 2009

Psychiatry Investig

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ObjectiveBorna disease virus (BDV) is a highly neurotropic agent causing various neuropsychiatric symptoms in animals. Over the past two decades, it has been suggested that BDV might be associated with human psychiatric diseases. We aimed to investigate whether BDV is associated with psychiatric patients in Korea.MethodsWe recruited 60 normal controls and 198 psychiatric patients (98 patients with depressive disorder, 60 with schizophrenia, and 40 with bipolar disorder). We used an indirect immunofluorescence antibody (IFA) test for the BDV antibody and a real-time reverse transcriptase polymerase chain reaction (rRT-PCR) assay for p24 and p40 RNA from peripheral blood mononuclear cells (PBMCs).ResultsNeither the BDV antibody nor p24, p40 RNA was detected in controls and patients groups.ConclusionOur results suggest that BDV might not be associated with psychiatric patients in Korea.

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“…Borna disease virus RNA positivity was detected in patients with psychotic disorders (44.4%), relatives without mental disorders (50%), relatives with mental disorders (37.5%) and healthy controls (14.8%) [25]. …”

Section: Discussionmentioning

confidence: 99%

Borna disease virus (BDV) circulating immunocomplex positivity in addicted patients in the Czech Republic: a prospective cohort analysis

2010

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BackgroundBorna disease virus (BDV) is an RNA virus belonging to the family Bornaviridae. Borna disease virus is a neurotropic virus that causes changes in mood, behaviour and cognition. BDV causes persistent infection of the central nervous system. Immune changes lead to activation of infection. Alcohol and drug dependence are associated with immune impairment.MethodsWe examined the seropositivity of BDV circulating immunocomplexes (CIC) in patients with alcohol and drug dependence and healthy individuals (blood donors). We examined 41 addicted patients for the presence of BDV CIC in the serum by ELISA at the beginning of detoxification, and after eight weeks of abstinence. This is the first such study performed in patients with alcohol and drug dependence.ResultsBDV CIC positivity was detected in 36.59% of addicted patients on day 0 and in 42.86% on day 56. The control group was 37.3% positive. However, we did not detect higher BDV CIC positivity in addicted patients in comparison with blood donors (p = 0.179). The significantly higher level of BDV CIC was associated with lower levels of GGT (gamma glutamyl transferase) (p = 0.027) and approached statistical significance with the lower age of addicted patients (p = 0.064). We did not find any association between BDV CIC positivity and other anamnestic and demographic characteristics.ConclusionsIn our study addicted patients did not have significantly higher levels of BDV CIC than the control group. The highest levels of BDV CIC were detected in patients with lower levels of GGT and a lower age.Trial registrationThis study was approved by the ethical committee of the University Hospital Medical Faculty of Charles University in Pilsen, Czech Republic (registration number 303/2001).

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RNA from Borna disease virus in patients with schizophrenia, schizoaffective patients, and in their biological relatives

Cited by 28 publications

References 51 publications

Anti‐Borna disease virus antibody responses in psychiatric patients: Long‐term follow up

Anti‐Borna disease virus antibody responses in psychiatric patients: Long‐term follow up

Failure to Detect Borna Disease Virus Antibody and RNA from Peripheral Blood Mononuclear Cells of Psychiatric Patients

Borna disease virus (BDV) circulating immunocomplex positivity in addicted patients in the Czech Republic: a prospective cohort analysis

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