RNA Editing: A Contributor to Neuronal Dynamics in the Mammalian Brain

Behm, Mikaela; Öhman, Marie

doi:10.1016/j.tig.2015.12.005

Cited by 131 publications

(150 citation statements)

References 112 publications

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“…Many of the best-characterized recoding sites are in brain-specific transcripts coding for membrane receptors and ion channels (Behm and Öhman 2016). For 183 such positions selected from our editing collection and the RADAR database, RNA editing activity was higher in neurons than other cell types (Fig.…”

Section: Resultsmentioning

confidence: 97%

“…ADARs are extremely important for the maintenance of cell homeostasis as mouse null mutants develop epileptic seizures and die several weeks after birth (Higuchi et al 2000;Horsch et al 2011). In addition, dysregulated RNA editing levels at specific recoding sites have been linked with a variety of diseases including neurological or psychiatric disorders and cancer (Chen et al 2013;Behm and Öhman 2016;Khermesh et al 2016).…”

Section: Introductionmentioning

confidence: 99%

“…Our comprehensive catalog indicates strong tissue specificity of RNA editing and reveals the brain to be the human tissue with the most specific modifications. Indeed, A-to-I editing is required for neuronal function as many targets are key mediators of synaptic signaling (Mattick and Mehler 2008;Behm and Öhman 2016).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Single-cell transcriptomics reveals specific RNA editing signatures in the human brain

Picardi

Horner

Pesole

2017

RNA

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While RNA editing by A-to-I deamination is a requisite for neuronal function in humans, it is under-investigated in single cells. Here we fill this gap by analyzing RNA editing profiles of single cells from the brain cortex of living human subjects. We show that RNA editing levels per cell are bimodally distributed and distinguish between major brain cell types, thus providing new insights into neuronal dynamics.

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Section: Resultsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Single-cell transcriptomics reveals specific RNA editing signatures in the human brain

Picardi

Horner

Pesole

2017

RNA

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“…There is a progressive expansion of enzymes that impart RNA editing and the extent of RNA editing in the brain during cognitive evolution (Mattick and Mehler 2008;Behm and Öhman 2016). A clear example of this expansion is the family of adenosine deaminases acting on RNA (ADARs), responsible for the editing of adenosine to inosine, thus increasing gene product diversity, particularly in primates (Paz-Yaacov et al 2010).…”

Section: Introductionmentioning

confidence: 99%

The RNA modification landscape in human disease

Jonkhout

Tran

Smith

et al. 2017

RNA

470

420

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RNA modifications have been historically considered as fine-tuning chemo-structural features of infrastructural RNAs, such as rRNAs, tRNAs, and snoRNAs. This view has changed dramatically in recent years, to a large extent as a result of systematic efforts to map and quantify various RNA modifications in a transcriptome-wide manner, revealing that RNA modifications are reversible, dynamically regulated, far more widespread than originally thought, and involved in major biological processes, including cell differentiation, sex determination, and stress responses. Here we summarize the state of knowledge and provide a catalog of RNA modifications and their links to neurological disorders, cancers, and other diseases. With the advent of direct RNA-sequencing technologies, we expect that this catalog will help prioritize those RNA modifications for transcriptome-wide maps.

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“…miRNA regulates gene expression by binding to complementary sequences (Vidigal and Ventura 2015). Numerous studies showed the close relationship between microRNA and neuronal development (Behm and Ohman 2016). Especially, miR133b is expressed in the DA neurons and is deficient in PD patients.…”

Section: Microrna-mediated Conversion Into Dopamine Neurons From Fibrmentioning

confidence: 99%

Direct conversion from skin fibroblasts to functional dopaminergic neurons for biomedical application

Jang

Jung

2017

biomed dermatol

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Recent progress in tissue engineering research led to the generation of different types of cells from a handful of skin tissue. Lineage reprogramming is a nascent field, which holds great potential to expand its use in regenerative medicine and disease modeling. The concept of somatic cell epigenetic stability has been fundamentally reshaped through the report of direct conversion of somatic identity to another lineage by introducing transcription factors. Here, we review recent advances in lineage reprogramming research, especially direct conversion into dopamine neurons from fibroblasts.

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RNA Editing: A Contributor to Neuronal Dynamics in the Mammalian Brain

Cited by 131 publications

References 112 publications

Single-cell transcriptomics reveals specific RNA editing signatures in the human brain

Single-cell transcriptomics reveals specific RNA editing signatures in the human brain

The RNA modification landscape in human disease

Direct conversion from skin fibroblasts to functional dopaminergic neurons for biomedical application

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