Abstract:Transcriptionally dysregulated cancers are sensitive to the inhibition of RNA Polymerase II (RNAPII) -driven gene expression. The therapeutic effect is attributed to selective inhibition of discrete oncogenes regulated at the chromatin level, however the role of RNA stability remains largely unexplored. Using integrated transcriptomic technologies, we discovered that RNA decay is a key determinant in defining gene expression responses to transcriptional perturbation, where total RNA signatures are dominated wi… Show more
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