RNA-binding proteins in degenerative joint diseases: A systematic review

Xiang, Min; Liu, Ling; Wu, Tingrui; Wei, Bo; Liu, Huan

doi:10.1016/j.arr.2023.101870

Cited by 3 publications

(15 citation statements)

References 195 publications

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“…35 Due to recent advancements in RNA-based technologies, [36][37][38] increasing evidence has shown that RNA-regulatory networks controlled by RBPs are also involved in the pathogenesis of IDD and OA. [39][40][41][42][43][44] IDD and OA are degenerative joint diseases, and RBPs may be involved in the co-pathogenesis. The RBPs implicated in IDD or OA are summarized in Table 1.…”

Section: Introductionmentioning

confidence: 99%

“…59,60 It has been implicated in the pathogenesis of IDD and OA. 39,40,61,62 HuR has been reported to be involved in the regulation of mRNA translation and stability. 59,60 HuR binds to specific mRNAs and transports bound mRNAs from the nucleus to the cytoplasm.…”

Section: Introductionmentioning

confidence: 99%

“…59,60 First, recent studies have demonstrated that the expression of HuR is involved in PTGR during IDD and OA through multiple distinct mechanisms. 39,40,61,62 First, the regulation of degeneration and synthesis of ECM factors plays an essential role in maintaining the homeostasis of articular cartilage. 39 The ECM homeostasis might be disrupted, and the degeneration exceeds the synthesis of ECM, contributing to the development of OA.…”

Section: Introductionmentioning

confidence: 99%

“…39,40,61,62 First, the regulation of degeneration and synthesis of ECM factors plays an essential role in maintaining the homeostasis of articular cartilage. 39 The ECM homeostasis might be disrupted, and the degeneration exceeds the synthesis of ECM, contributing to the development of OA. Articular cartilage ECM is mainly composed of collagen type II (Col II) and aggrecan (ACAN) regulated by synthesis factor SOX9.…”

Section: Introductionmentioning

confidence: 99%

“…68,69 MMP-13 is an AREcontaining mRNA associated with the PTGR by HuR. 39,70 Knockdown of HuR is associated with a decreased level of MMP-13. However, HuR might not regulate MMP-13 through the mRNA stability regulation mechanism; alternatively, it inhibits the expression of MMP-13 suppressers, including RUNX2, SP1, and USF1.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Emerging roles of RNA binding proteins in intervertebral disc degeneration and osteoarthritis

Li,

Gao

et al. 2023

Orthopaedic Surgery

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The etiology of intervertebral disc degeneration (IDD) and osteoarthritis (OA) is complex and multifactorial. Both predisposing genes and environmental factors are involved in the pathogenesis of IDD and OA. Moreover, epigenetic modifications affect the development of IDD and OA. Dysregulated phenotypes of nucleus pulposus (NP) cells and OA chondrocytes, including apoptosis, extracellular matrix disruption, inflammation, and angiogenesis, are involved at all developmental stages of IDD and OA. RNA binding proteins (RBPs) have recently been recognized as essential post‐transcriptional regulators of gene expression. RBPs are implicated in many cellular processes, such as proliferation, differentiation, and apoptosis. Recently, several RBPs have been reported to be associated with the pathogenesis of IDD and OA. This review briefly summarizes the current knowledge on the RNA‐regulatory networks controlled by RBPs and their potential roles in the pathogenesis of IDD and OA. These initial findings support the idea that specific modulation of RBPs represents a promising approach for managing IDD and OA.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Emerging roles of RNA binding proteins in intervertebral disc degeneration and osteoarthritis

Li,

Gao

et al. 2023

Orthopaedic Surgery

View full text Add to dashboard Cite

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MicroRNA-targeting nanomedicines for the treatment of intervertebral disc degeneration

Genedy,

Humbert,

Laoulaou

et al. 2024

Advanced Drug Delivery Reviews

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Expression landscape of RNA-binding proteins (RBPs) during adipogenesis and diet-induced obesity

Dairi,

Alswaji,

Alzahrani

et al. 2023

Preprint

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RNA-binding proteins (RBPs) are key regulators of various cellular processes, including mRNA splicing, transport, stability, and translation. They play a crucial role in post-transcriptional gene regulation by interacting with specific RNA sequences or structures. RBPs can also influence the localization of mRNAs within the cell and participate in the formation of RNA-protein complexes that control gene expression. Dysregulation or mutations in RBPs have been associated with a wide range of diseases, including neurodegenerative disorders, cancer, and developmental abnormalities. Recent studies have highlighted the importance of RBPs in regulating adipocyte differentiation, lipid metabolism, and insulin sensitivity. However, the global expression patterns and functional contributions of RBPs during adipogenesis and in regulating adipocyte functioning remain poorly understood. Identifying and characterizing RBPs during adipogenesis could provide valuable insights into the molecular mechanisms underlying adipocyte differentiation and potentially lead to the development of novel therapeutic strategies for obesity-related disorders. Using a combination of bioinformatics tools and experimental validation, we identified a set of novel RBPs that may have important roles in adipogenesis and adipocyte functioning. We analyzed the expression of the entire repertoire of RBPs during the adipogenic differentiation of murine adipocyte cell line, 3T3-L1 and assessed the expression of RBPs in stromal vesicular fraction (SVF) and adipocyte fraction of mouse epididymal adipose tissue. We also evaluated the impact of high fat diet on the expression of RBPs in adipocytes isolated from mouse epididymal adipose tissue. We found a number of RBPS that were significantly up- or down-regulated in 3T3-L1 cells during adipogenic differentiation and were enriched in the stromal vascular fraction (SVF) or adipocyte fraction of mouse adipose tissue. In addition, they exhibited differential expression in adipocytes isolated from diet-induced obese mice compared to control mice. The majority of these RBPs have no known role in adipogenesis or adipose metabolism. These proteins could potentially play a novel role in adipogenic differentiation and adipose metabolism, suggesting the presence of previously unknown regulatory mechanisms. Further investigation is needed to understand the specific functions of these RBPs and their potential impact on adipose tissue development and metabolism. This discovery opens up new avenues for research in uncovering the intricate regulatory networks involved in adipogenesis and adipose tissue homeostasis.

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RNA-binding proteins in degenerative joint diseases: A systematic review

Cited by 3 publications

References 195 publications

Emerging roles of RNA binding proteins in intervertebral disc degeneration and osteoarthritis

Emerging roles of RNA binding proteins in intervertebral disc degeneration and osteoarthritis

MicroRNA-targeting nanomedicines for the treatment of intervertebral disc degeneration

Expression landscape of RNA-binding proteins (RBPs) during adipogenesis and diet-induced obesity

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