RNA-binding protein LIN28 is a sensitive marker of pediatric yolk sac tumors

Feng, Shaoguang; Huang, Su; Tong, Yulong; Chen, Zhongliang; Shen, Delei; Wu, Dazhou; Lai, Xin‐He; Chen, Xiaoming

doi:10.1007/s00383-016-3922-1

Cited by 6 publications

(4 citation statements)

References 19 publications

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“…LIN28 is a novel sensitive and relatively specific diagnostic marker for pediatric YSTs, with advantages over AFP in diagnosing pediatric YSTs. 12 The present tumor was also positive for LIN28, favoring a diagnosis of YST. SALL4 is a 100% sensitive diagnostic marker for extragonadal YST.…”

Section: Discussionsupporting

confidence: 51%

Primary Pediatric Yolk Sac Tumor of Liver With Lung Metastasis: An Unusual Presentation With Diagnosis Aided by LIN28 Immunohistochemistry

Sekar

Pradeep²,

Srinivas

et al. 2023

Int J Surg Pathol

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Yolk sac tumor is a malignant germ cell tumor, which typically occurs in the gonads with elevated serum alpha-fetoprotein (AFP). Among extragonadal sites, the liver is an uncommon location for primary pediatric yolk sac tumors. Other common hepatic tumors in this age group presenting with elevated serum AFP like hepatoblastoma and hepatocellular carcinoma must be differentiated from yolk sac tumors for initiating appropriate treatment and accurate prognostication. Lung metastasis with refractoriness to chemotherapy is an extraordinary presentation that has never been documented in the literature. We report our experience with a 2-year-old female child initially misdiagnosed as hepatoblastoma. It was found that LIN28 positivity by immunohistochemistry aided in confirmation of the histopathological diagnosis of primary yolk sac tumor of the liver.

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Section: Discussionsupporting

confidence: 51%

Primary Pediatric Yolk Sac Tumor of Liver With Lung Metastasis: An Unusual Presentation With Diagnosis Aided by LIN28 Immunohistochemistry

Sekar

Pradeep²,

Srinivas

et al. 2023

Int J Surg Pathol

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“…Performing a central pathomorphological examination can be helpful in the case of these neoplasms. Perhaps new tumor markers, like the ones discovered by Feng et al will help eliminate mistakes in pathomorphological diagnoses [ 24 ]. Grading was available only in one patient in our study and no Heifetz lesions were observed.…”

Section: Discussionmentioning

confidence: 99%

Ovarian teratoma in children: a plea for collaborative clinical study

Łuczak

Bagłaj

2018

J Ovarian Res

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BackgroundAlthough teratomas are the most common histologic subtype of childhood ovarian germ cell tumors, their appropriate treatment in this age group still remains unclear. Paucity of research dedicated exclusively to both mature and immature teratomas of the ovary, contribute to decision making difficulties.Therefore, we decided to review retrospectively our experience in treatment of pediatric ovarian teratomas in order to assess the epidemiology, presenting features, and diagnostic as well as surgical management of these lesions.ResultsThe study comprised 58 patients. Fifty percent of patients were between 9 and 15 years old. Mature teratoma was diagnosed in 55(94.83%) patients, while 3(5.17%) patients presented with immature teratoma. Twenty eight (50.91%) girls with mature teratoma had laparotomy and 23 (41.82%) had laparoscopy performed as an initial operative approach. Ovarian tissue sparing technique (preservation of the ovarian tissue of the affected gonad) was applied in only 11.11% of patients operated in the first study period (years 1999–2003) and increased to 40.54% in the second half of our study (years 2004–2016). The extent of gonadal resection was not related with the size of the lesion. Bilateral lesions were noted in 8 patients with mature teratoma. All girls with immature teratoma were subjected to formal laparotomy. Two patients had stage III of the disease and one had stage IV. They underwent at least resection of the affected gonad. Adjuvant chemotherapy was given to all girls with immature teratoma after the surgery.ConclusionsUnder particular conditions ovarian-sparing surgery might be successfully applied in children with mature teratoma. Laparotomy is the treatment of choice in large masses, suspicious for malignancy and if surgical staging is required. High quality prospective multi-institutional studies are required in order to get an objective insight into biology and prognostic factors of teratomas in children.

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“… 7 Maybe new tumor markers, like the ones discovered by Feng et al (RNA-binding protein LIN28) will help eliminate mistakes in pathomorphological diagnoses. 17 …”

Section: Discussionmentioning

confidence: 99%

“…7 Maybe new tumor markers, like the ones discovered by Feng et al (RNA-binding protein LIN28) will help eliminate mistakes in pathomorphological diagnoses. 17 In a recent study, ovarian tissue sparing technique for mature teratoma was applied in only 11.11% of patients operated before 2003 and increased to 40.54% after this year. The preservation rate was higher in the group of girls in whom laparoscopic technique was chosen.…”

Section: Dovepressmentioning

confidence: 99%

Diagnosis Difficulties and Minimally Invasive Treatment for Ovarian Masses in Adolescents

Ţarcă¹,

Trandafir²,

Cojocaru³

et al. 2022

IJWH

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About 1% of childhood tumors can be malignant ovarian tumors and differential diagnosis with benign ones is sometimes difficult before surgery. Concerning the management of such tumors in adolescents for which future fertility is a concern, there is specific interest in their malignant potential and the possible use of ovarian-sparing operative techniques, as well the suitability of chemotherapy. To exemplify the difficulties of preoperative differential diagnosis, personalized approach and the difficulties of deciding to preserve the affected ovary, we report a rare case of a 14-year-old female adolescent with a growing abdominal painless mass and without any other chronic diseases. After physical examination and imaging investigations, laparoscopic surgical procedure is performed, the peritoneal cavity is explored and the well-delimited gigantic tumor is removed. Considering the normally looking pelvis and absence of adenopathy, as well as the patient’s age and wish to have children, both ovaries are preserved. Laparoscopy has become the gold standard in the management of this condition, although there are few studies that report this approach in children; the differential diagnosis between a benign and a malignant tumor cannot be established exactly until after the histological examination, which revealed in our case a cystic teratoma with mature tissues. A better understanding of clinical features and evolution of giant ovarian masses in adolescents could help clinicians better diagnose and treat such lesions.

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RNA-binding protein LIN28 is a sensitive marker of pediatric yolk sac tumors

Abstract: LIN28 is a sensitive marker for pediatric YSTs and it can be used to distinguish them from mature teratomas. LIN28 is likely to become a new and valuable biomarker for diagnosing of pediatric YST.

Cited by 6 publications

References 19 publications

Primary Pediatric Yolk Sac Tumor of Liver With Lung Metastasis: An Unusual Presentation With Diagnosis Aided by LIN28 Immunohistochemistry

Primary Pediatric Yolk Sac Tumor of Liver With Lung Metastasis: An Unusual Presentation With Diagnosis Aided by LIN28 Immunohistochemistry

Ovarian teratoma in children: a plea for collaborative clinical study

Diagnosis Difficulties and Minimally Invasive Treatment for Ovarian Masses in Adolescents

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