RNA as a means of inter-species communication and manipulation: Progresses and shortfalls

Asgari, Sassan

doi:10.1080/15476286.2017.1306172

Cited by 6 publications

(3 citation statements)

References 8 publications

(5 reference statements)

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“…Interestingly, exosomal microvesicles may play a role in cell-cell communication by acting as vehicles for the transfer of miRNAs (and other macromolecules), as clearly shown for exosomal miRNAs released from the adipose tissue and regulating the expression of mRNA targets in the liver 35 . This exosome-mediated miRNA transfer between cells may take place not only within the same organism but also across species, and several representative cases of involvement of small non-coding RNAs in cross-species interactions can be found in the context of the evolutionary arms race between pathogens and their hosts [64][65][66][67] . For example, the parasitic worms H. polygyrus, B. malayi and Schistosoma japonicum, which establish long-lasting infections of their hosts, release exosomes carrying miRNAs with immunomodulatory activity 33,34,38,68,69 .…”

Section: Discussionmentioning

confidence: 99%

MicroRNAs and other small RNAs in Aedes aegypti saliva and salivary glands following chikungunya virus infection

Fiorillo

Yen

Colantoni

et al. 2022

Sci Rep

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Mosquito saliva facilitates blood feeding through the anti-haemostatic, anti-inflammatory and immunomodulatory properties of its proteins. However, the potential contribution of non-coding RNAs to host manipulation is still poorly understood. We analysed small RNAs from Aedes aegypti saliva and salivary glands and show here that chikungunya virus-infection triggers both the siRNA and piRNA antiviral pathways with limited effects on miRNA expression profiles. Saliva appears enriched in specific miRNA subsets and its miRNA content is well conserved among mosquitoes and ticks, clearly pointing to a non-random sorting and occurrence. Finally, we provide evidence that miRNAs from Ae. aegypti saliva may target human immune and inflammatory pathways, as indicated by prediction analysis and searching for experimentally validated targets of identical human miRNAs. Overall, we believe these observations convincingly support a scenario where both proteins and miRNAs from mosquito saliva are injected into vertebrates during blood feeding and contribute to the complex vector–host–pathogen interactions.

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Section: Discussionmentioning

confidence: 99%

MicroRNAs and other small RNAs in Aedes aegypti saliva and salivary glands following chikungunya virus infection

Fiorillo

Yen

Colantoni

et al. 2022

Sci Rep

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“…This suggested that certain types of food, beyond being a source of macro-or micro-nutrients, bioactive molecules, and energy, might also provide biologically active sncRNA. Although the possibility of systemic effects is still open (see paragraph 4 for more details), the exposure to exogenous sncRNA coming from food has been reported (Ledda, Ottaggio, Izzotti, Sukkar & Miele, 2020;Li et al, 2018;Sanchita, Trivedi, Asif & Trivedi, 2018;Vaucheret & Chupeau, 2012), and the possibility that they might exert significant biological effects in mammals needs further study (Asgari, 2017;Nguyen, 2020).…”

Section: Inter-species Gene Expression Regulation Through Small Non-c...mentioning

confidence: 99%

The neglected nutrigenomics of milk: What is the role of inter-species transfer of small non-coding RNA?

Bordoni

Gabbianelli

2021

Food Bioscience

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“…Numerous are the examples of interspecies and even interkingdom RNA-based communication, especially those concerning host–parasite/symbiont interactions. The study of RNA-based transfer of information promises not only to bring fundamental insights into a novel layer of regulatory complexity, but also to open doors to a handful of biotechnological applications [ 26 , 27 , 28 ].…”

Section: Introduction: Regulatory Rnas and Insect-plant Interactiomentioning

confidence: 99%

RNAs on the Go: Extracellular Transfer in Insects with Promising Prospects for Pest Management

Santos

Remans

Brande

et al. 2021

Plants

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RNA-mediated pathways form an important regulatory layer of myriad biological processes. In the last decade, the potential of RNA molecules to contribute to the control of agricultural pests has not been disregarded, specifically via the RNA interference (RNAi) mechanism. In fact, several proofs-of-concept have been made in this scope. Furthermore, a novel research field regarding extracellular RNAs and RNA-based intercellular/interorganismal communication is booming. In this article, we review key discoveries concerning extracellular RNAs in insects, insect RNA-based cell-to-cell communication, and plant–insect transfer of RNA. In addition, we overview the molecular mechanisms implicated in this form of communication and discuss future biotechnological prospects, namely from the insect pest-control perspective.

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RNA as a means of inter-species communication and manipulation: Progresses and shortfalls

Cited by 6 publications

References 8 publications

MicroRNAs and other small RNAs in Aedes aegypti saliva and salivary glands following chikungunya virus infection

MicroRNAs and other small RNAs in Aedes aegypti saliva and salivary glands following chikungunya virus infection

The neglected nutrigenomics of milk: What is the role of inter-species transfer of small non-coding RNA?

RNAs on the Go: Extracellular Transfer in Insects with Promising Prospects for Pest Management

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