RNA and DNA in Melanosomes of Hamster Melanoma

Abstract

The melanosomes were isolated from Syrian hamster melanoma Ma by three different methods. Levels of about 0.2% RNA and less than 0.05% of DNA were detected in the melanosome preparations. The higher the purification of the melanosome samples, the lower the DNA content observed. Consequently, traces of DNA in melanosomes could originate from contamination. The irreversible interaction of DNA with melanosomes in vitro was not demonstrated.

Skin detoxification cycles

“…In this same sense, there are reports that identify and purify RNA in mature melanosomes of the hamster melanoma. [6] These ribonucleic acids could be transferred to keratinocytes and to cells of the tumoral microenvironment, where they might then carry out their function, whether by translating for or forming part of the families of microRNAs regulators of gene expression [ Figures 1a and b]. …”