RM-043 Eruptive seborrheic keratosis (ESK) and its association with gastrointestinal cancer (GIC): a case-control study and meta-analysis

Insuasty, Jesús; Díaz, Luis A.; Berbeo, Mario Jahir Chávez; Ballesteros, Zully Johanna; Mantilla, A.

doi:10.1093/annonc/mdw201.40

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“…Given the small sample size, no conclusions could be made on the association between ESK and malignancy. 16 - 18 Another criticism of ESK’s link to malignancy is that the incidence of both seborrheic keratoses and cancer is higher in older patients. 24 While the majority of patients were elderly in our analysis, we found that 31.4% ( n = 22/70) of patients who had ESK prior to a cancer diagnosis were under the age of 60.…”

Section: Discussionmentioning

confidence: 99%

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Eruptive Seborrheic Keratoses Are Associated With a Co-Occurring Malignancy in the Majority of Reported Cases: A Systematic Review

et al. 2021

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Background Eruptive seborrheic keratoses (ESK) is a benign skin condition that has been associated with malignant and nonmalignant diseases. We conducted a systematic review of reported cases of ESK to identify and summarize associated comorbidities. Methods MEDLINE and Embase were searched from database inception (1946) to July 31, 2020 for original articles describing ESK with or without a co-occurring condition. Subject demographics, as well as details of ESK and associated diagnoses were extracted from 76 articles (70 case reports, 3 case series, 3 case control studies) representing 92 patients. Results In total, 76.1% ( n = 70/92) of patients with ESK had a co-occurring malignancy, 4.3% ( n = 4/92) presented with a nonmalignant condition, 9.8% ( n = 9/92) experienced ESK as an adverse drug reaction, and 9.8% ( n = 9/92) did not report any underlying medical condition. ESK preceded a cancer diagnosis in 76.1% ( n = 70/92) of patients with a mean latency period of 4.0 months (range: 0.25-9 months). The most common malignancies associated with ESK were cutaneous T-cell lymphoma ( n = 10/70, 14.3%) and gastrointestinal adenocarcinoma ( n = 9/70, 12.9%). ESK preceded nonmalignant conditions or no disease in 14.1% ( n = 13/92) of patients with a mean latency period of 3.1 months (range: 0.75-6 months). Drug-induced ESK occurred in 9.8% ( n = 9/92) of patients with a mean latency period of 7.1 weeks after changing medication. Conclusion Although the role of ESK as a paraneoplastic cutaneous marker is debated, healthcare providers should consider screening for underlying malignancy in patients presenting with ESK. Larger studies are needed to confirm its role as a marker for disease.

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Section: Discussionmentioning

confidence: 99%

“…Given the low incidence rate, an association between ESK and malignancy could not be made. [16][17][18]…”

Section: Malignant Conditionsmentioning

confidence: 99%

Eruptive Seborrheic Keratoses Are Associated With a Co-Occurring Malignancy in the Majority of Reported Cases: A Systematic Review

et al. 2021

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RM-043 Eruptive seborrheic keratosis (ESK) and its association with gastrointestinal cancer (GIC): a case-control study and meta-analysis

Abstract: Conclusion:In Colombian patients, seborrheic keratosis and eruptive seborrheic keratosis of less than 6 months onset is highly suggestive of an association with gastrointestinal cancer. Additional studies are required to confirm this association.

Cited by 1 publication

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Eruptive Seborrheic Keratoses Are Associated With a Co-Occurring Malignancy in the Majority of Reported Cases: A Systematic Review

Eruptive Seborrheic Keratoses Are Associated With a Co-Occurring Malignancy in the Majority of Reported Cases: A Systematic Review

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