19Understanding the combined and separate effects of climate and land use change on the water cycle is 20 necessary to mitigate negative impacts. However, existing methodologies typically divide data into 21 discrete (before and after) periods, implicitly representing climate and land use as step changes when in 22 reality these changes are often gradual. Here, we introduce a new regression-based methodological 23 framework designed to separate climate and land use effects on any hydrological flux of interest 24 continuously through time, and estimate uncertainty in the contribution of these two drivers. We present 25 two applications in the Yahara River watershed (Wisconsin, USA) demonstrating how our approach can 26 be used to understand synergistic or antagonistic relationships between land use and climate in either the 27 past or the future: (1) historical streamflow, baseflow, and quickflow in an urbanizing subwatershed; and 28(2) simulated future evapotranspiration, drainage, and direct runoff from a suite of contrasting climate and 29 land use scenarios for the entire watershed. In the historical analysis, we show that ~60% of recent 30 streamflow changes can be attributed to climate, with approximately equal contributions from quickflow 31 and baseflow. However, our continuous method reveals that baseflow is significantly increasing through 32 time, primarily due to land use change and potentially influenced by long-term increases in groundwater 33 storage. In the simulation of future changes, we show that all components of the future water balance will 34 respond more strongly to changes in climate than land use, with the largest potential land use effects on 35 drainage. These results indicate that diverse land use change trajectories may counteract each other while 36 the effects of climate are more homogeneous at watershed scales. Therefore, management opportunities to 37 counteract climate change effects will likely be more effective at smaller spatial scales, where land use 38 trajectories are unidirectional. 39