Rivastigmine reverses aluminum-induced behavioral changes in rats

Abdel-Aal, Raafat A.; Assi, Abdel-Azim; Kostandy, Botros B.

doi:10.1016/j.ejphar.2011.03.011

Cited by 68 publications

(35 citation statements)

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“…In the probe trial, each rat was allowed to enter the illuminated chamber and the transition time interval between illuminated and dark chambers recorded as step‐through latency. If the animal did not enter the dark chamber within 5 min, the test was terminated and the step‐through latency recorded during early 300 s (Abdel‐Aal et al, 2011; Esfandiary et al, 2015; Mazzola et al, 2003; Venault et al, 1986; Xie et al, 2017).…”

Section: Methodsmentioning

confidence: 99%

Quercetin promotes learning and memory performance concomitantly with neural stem/progenitor cell proliferation and neurogenesis in the adult rat dentate gyrus

Karimipour¹,

Rahbarghazi‬

Tayefi

et al. 2019

Intl J of Devlp Neuroscience

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The decline in neurogenesis is a very critical problem in Alzheimer disease. Different biological activities have been reported for medicinal application of quercetin. Herein, we investigated the neurogenesis potential of quercetin in a rat model of Alzheimer's disease induced by amyloid‐beta injection. Rats were randomly divided into Control, Alzheimer + Saline and Alzheimer + Quercetin groups. Following the administration of Amyloid‐beta, rats in the Alzheimer + Quercetin group received 40 mg/kg/day quercetin orally for one month. Our data demonstrated amyloid‐β injection could impair learning and memory processing in rats indicated by passive avoidance test evaluation. We noted that one‐month quercetin treatment alleviated the detrimental effects of amyloid‐β on spatial learning and memory parameters using Morris water maze analysis. Quercetin was found to increase the number of proliferating neural stem/progenitor cells. Notably, quercetin increased the number of DCX‐expressing cells, indicating the active dynamic growth of neural progenitor cells in the dentate gyrus of the hippocampus. We further observed that the quercetin improved the number of BrdU/NeuN positive cells contributed to enhanced adult neurogenesis. Based on our results, quercetin had the potential to promote the expression of BDNF, NGF, CREB, and EGR‐1 genes involved in regulating neurogenesis. These data suggest that quercetin can play a valuable role in alleviating Alzheimer's disease symptoms by enhancing adult neurogenesis mechanism.

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Section: Methodsmentioning

confidence: 99%

Quercetin promotes learning and memory performance concomitantly with neural stem/progenitor cell proliferation and neurogenesis in the adult rat dentate gyrus

Karimipour¹,

Rahbarghazi‬

Tayefi

et al. 2019

Intl J of Devlp Neuroscience

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“…No neurobehavioral assessment (Shati et al 2011) or only limited details of the conditions during the behavioral and neuromotor assays (e.g., blind examination) detract from these reports. Results from the Abdel-Aal et al (2011a) study suggest that high-dose AlCl 3 injections over a prolonged period can reduce locomotor and cognitive functions in rats, but the reductions in cognitive function and physical activity occurred at doses that also reduced body weight gain suggesting that repeated AlCl 3 injections induced systemic toxicity.…”

Section: Organ Systems and Functionmentioning

confidence: 97%

“…Li et al (2012a) compared APP expression in the brain and selected internal organs of rats after ip injection of AlCl 3 at 1 mg Al/kg once every other day over 60 days. Abdel-Aal et al (2011a) gave daily ip injections of AlCl 3 at 100 mg/kg-day for 60 days to male Wistar albino rats. Common limitations include only a single Al dose level, no details on clinical signs, food or drinking water consumption or the chemical purity of the test material and the pH of the administered AlCl 3 solution or the Al content in the laboratory stock diet and drinking water were not reported.…”

Section: Organ Systems and Functionmentioning

confidence: 99%

“…The designs of exploratory studies (e.g., Abdel-Aal et al 2011a, 2011b, Abu-Taweel et al 2011a, 2011b, Akiyama et al 2012, Cheng et al 2012, Cui et al 2012, Elsaid et al 2011, Garrosa et al 2011, Kumar et al 2011, Moselhy et al 2011, Sun et al 2011b, Thirunavukkarasu et al 2010, 2011, 2012, Viezeliene et al 2011, 2012, Wang et al 2010a, Xiao et al 2011) and of even those that meet current regulatory guidelines (e.g., Hirata-Koizumi et al 2011a, 2011b) failed to include concurrent controls treated in an identical manner with equimolar doses of the hydrolysis products (e.g., HCl, H 2 SO 4 ). It is clear these hydrolysis products confound the interpretation of in vivo (e.g., Hirata-Koizumi et al 2011a) and in vitro (Castorina et al 2010, Cifone et al 1987, Güngör et al 2010, Kamalov et al 2011, Morita et al 1989, 1992) data, particularly where media Al concentrations ≥ 10 μM are equivalent to lethal or near-lethal serum Al concentrations in humans (Krewski et al 2007).…”

Section: Synthesis and Conclusionmentioning

confidence: 99%

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Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts

Willhite¹,

Karyakina²,

Yokel³

et al. 2014

Critical Reviews in Toxicology

332

201

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Aluminum (Al) is a ubiquitous substance encountered both naturally (as the third most abundant element) and intentionally (used in water, foods, pharmaceuticals, and vaccines); it is also present in ambient and occupational airborne particulates. Existing data underscore the importance of Al physical and chemical forms in relation to its uptake, accumulation, and systemic bioavailability.Address for correspondence: Calvin C. Willhite, Risk Sciences International, 55 Metcalfe Street, Suite 700, Ottawa, ON, Canada. calvinwillhite@hotmail.com. Declaration of interestPartial funding for this work was provided by a contract to review the recent scientific literature on health effects of aluminum between the International Aluminium Institute (IAI, www.world-aluminium.org), the Aluminium Reach Consortium (ARC, www.aluminium-reach-consortium.eu), and Risk Sciences International (RSI, www.risksciences.com), a Canadian company established in 2006 in partnership with the University of Ottawa. Additional financial support was provided by the Natural Sciences and Engineering Research Council of Canada (NSERC) to D. Krewski, who holds the NSERC Chair in Risk Science at the University of Ottawa. C.C. Willhite, N.A. Karyakina, F. Momoli, and N. Yenugadhati were compensated by RSI for their contributions to the review. I. Arnold, T. Wisniewski and R. Yokel received no compensation from RSI for their contributions to this work. The authors, whose affiliations are shown on the title page, had sole responsibility for preparation of this paper, including determining the strategy for reviewing the scientific literature summarized in this article, synthesizing the findings, and drawing conclusions. Scientists associated with IAI/ARC were given the opportunity to review and offer technical comments on the paper, prior to submission to Critical Reviews in Toxicology. I. Arnold serves as a consultant to the International Aluminium Institute. None of the authors have appeared before regulatory agencies on behalf of the sponsors, or appeared as experts in legal proceedings concerning matters reviewed in this paper. The scientific opinions and conclusions expressed in the paper are exclusively those of the authors, and are independent of the sources of financial support. HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptThe present review represents a systematic examination of the peer-reviewed literature on the adverse health effects of Al materials published since a previous critical evaluation compiled by Krewski et al. (2007). The scientific literature on the adverse health effects of Al is extensive. Health risk assessments for Al must take into account individual co-factors (e.g., age, renal function, diet, gastric pH). Conclusions from the current review point to the need for refinement of the PTWI, reduction of Al contamination in PN solutions, justification for routine addition of Al to vaccines, and harmonization of OELs for Al substances.

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“…Locomotor activity and rearing were continuously monitored for 5 min and the data on locomotor activity were analysed as 1‐min bins. The number of pieces of excreted faeces during the period was counted as a measure of anxiety .…”

Section: Methodsmentioning

confidence: 99%

Altered Cerebellum Development and Dopamine Distribution in a Rat Genetic Model with Congenital Hypothyroidism

Shimokawa

Behnaz

Morioka

et al. 2014

J Neuroendocrinology

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Thyroid hormones play crucial roles in the development and functional maintenance of the central nervous system. Despite extensive studies of the neural function of thyroid hormones, little is known about the effects of hypothyroidism on behavioural traits and the mechanisms underlying such effects. In the present study, we report an investigation of congenitally hypothyroid mutant rdw rats, revealing a novel function of thyroid hormones in the central nervous system. The rdw rats were subjected to behavioural analyses such as the rotarod test, open field test and circadian activity measurement. To determine the cause of behavioural disorders, cerebellar morphogenesis was examined by immunohistochemical analysis, and the axonal transport of dopamine in the nigrostriatal pathway was analysed by high-performance liquid chromatography and western blotting. The effects of thyroxine administration to the rdw rats were examined by behavioural analysis. The rdw rats showed severe impairment of motor coordination and balance. This could be explained by the fact that the rats showed severe retardation of cerebellar morphogenesis, which correlates with the small somata and poor dendritic arborisation of Purkinje cells and retarded migration of granule cells particularly during the first two postnatal weeks. Moreover, the rdw rats showed hypoactivity, characterised by decreased circadian locomotor activity. After weaning, thyroxine administration improved the dwarfism in rdw rats but had no effect on cerebellar function. In addition, the rdw rats showed anxiety and depression intrinsically to novel surroundings. Interestingly, the rdw rats showed high levels of dopamine in the substantia nigra and low levels in the striatum, an important centre for the coordination of behaviour. Furthermore, low levels of tubulin in the striatum were detected, indicating the aberrant axonal transport of dopamine in the nigrostriatal pathway as a result of the reduced delivery of microtubules. These findings indicate an important function of thyroid hormones in cerebellar formation and in the regulation of axonal transport of dopamine. Moreover, rdw rats will be useful for studies of brain function and behavioural disorders in congenital hypothyroidism.

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Rivastigmine reverses aluminum-induced behavioral changes in rats

Cited by 68 publications

References 50 publications

Quercetin promotes learning and memory performance concomitantly with neural stem/progenitor cell proliferation and neurogenesis in the adult rat dentate gyrus

Quercetin promotes learning and memory performance concomitantly with neural stem/progenitor cell proliferation and neurogenesis in the adult rat dentate gyrus

Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts

Altered Cerebellum Development and Dopamine Distribution in a Rat Genetic Model with Congenital Hypothyroidism

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