Rivastigmine for the prevention of postoperative delirium in elderly patients undergoing elective cardiac surgery—A randomized controlled trial*

Gamberini, Melanie; Bolliger, Daniel; Buse, Giovanna Lurati; Burkhart, Christoph; Grapow, Martin; Gagneux, Alexa; Filipovic, Miodrag; Seeberger, Manfred D.; Pargger, Hans; Siegemund, Martin; Carrel, Thierry; Seiler, Walter O.; Berres, Manfred; Strebel, S.; Monsch, Andreas U.; Steiner, Luzius A.

doi:10.1097/ccm.0b013e31819da780

Cited by 231 publications

(185 citation statements)

References 28 publications

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“…Also, 60.4% of eligible patients consented to par ticipate, a higher percentage than in any compar able studies involving vulnerable elderly popula tions. 52 Therefore, our results have good external validity and can be extrapolated to other popula tions of patients with hip fracture. 53 Furthermore, we applied a clear definition of delirium based on the gold standard (DSMIV) definition.…”

Section: Discussionmentioning

confidence: 53%

Effect of melatonin on incidence of delirium among patients with hip fracture: a multicentre, double-blind randomized controlled trial

Jonghe

Munster

Goslings

et al. 2014

CMAJ

144

139

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Section: Discussionmentioning

confidence: 53%

Effect of melatonin on incidence of delirium among patients with hip fracture: a multicentre, double-blind randomized controlled trial

Jonghe

Munster

Goslings

et al. 2014

CMAJ

144

139

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“…Although haloperidol and various atypical antipsychotics have been used in the management of delirium in the past, there have been no reports to date proving their efficacy as treatments for ICU delirium, including postoperative delirium,223, 224, 225, 226, 227 and there are only a few studies that can assert to the efficacy of quetiapine 228. Currently, while the use of antipsychotics may slightly reduce the frequency of delirium onset, the consensus is that their routine use is not recommended, as it does not ultimately lead to improved patient prognosis while exposing them to various side effects including extrapyramidal symptoms, torsade de pointes, and ventricular arrhythmias 229.…”

Section: Introductionmentioning

confidence: 99%

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG2016)

Nishida

Ogura

Egi

et al. 2018

Acute Medicine & Surgery

157

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Background and PurposeThe Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG 2016), a Japanese‐specific set of clinical practice guidelines for sepsis and septic shock created jointly by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine, was first released in February 2017 in Japanese. An English‐language version of these guidelines was created based on the contents of the original Japanese‐language version.MethodsMembers of the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine were selected and organized into 19 committee members and 52 working group members. The guidelines were prepared in accordance with the Medical Information Network Distribution Service (Minds) creation procedures. The Academic Guidelines Promotion Team was organized to oversee and provide academic support to the respective activities allocated to each Guideline Creation Team. To improve quality assurance and workflow transparency, a mutual peer review system was established, and discussions within each team were open to the public. Public comments were collected once after the initial formulation of a clinical question (CQ), and twice during the review of the final draft. Recommendations were determined to have been adopted after obtaining support from a two‐thirds (>66.6%) majority vote of each of the 19 committee members.ResultsA total of 87 CQs were selected among 19 clinical areas, including pediatric topics and several other important areas not covered in the first edition of the Japanese guidelines (J‐SSCG 2012). The approval rate obtained through committee voting, in addition to ratings of the strengths of the recommendation and its supporting evidence were also added to each recommendation statement. We conducted meta‐analyses for 29 CQs. Thirty seven CQs contained recommendations in the form of an expert consensus due to insufficient evidence. No recommendations were provided for 5 CQs.ConclusionsBased on the evidence gathered, we were able to formulate Japanese‐specific clinical practice guidelines that are tailored to the Japanese context in a highly transparent manner. These guidelines can easily be used not only by specialists, but also by non‐specialists, general clinicians, nurses, pharmacists, clinical engineers, and other healthcare professionals.

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“…Oftast voru notuð greiningarviðmið DSM-IV 33,[36][37][38][39][40][41] eða stöðluð matstaeki. 31,[42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57] Algengi óráðs var laegst þegar greiningin byggði á öðrum greiningarviðmiðum og þar sem ekki fór fram reglubundin skimun eða mat á óráðseinkennum með stöðluðum matstaekjum. 58,59 Annar þáttur sem skýrir breytileikann er að úrtök rannsóknanna voru ólík varðandi aldur þátttakenda og þátttöku einstaklinga með þekkta heilabilun eða óráð fyrir skurðaðgerð.…”

Section: Niðurstöðurunclassified

Óráð eftir opna hjartaaðgerð: kerfisbundin samantekt á algengi, áhættuþáttum og afleiðingum

Þorsteinsdóttir¹,

Sveinsdóttir²,

Snædal³

2015

LBL

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Rivastigmine for the prevention of postoperative delirium in elderly patients undergoing elective cardiac surgery—A randomized controlled trial*

Abstract: This negative or, because of methodologic issues, possibly failed trial does not support short-term prophylactic administration of oral rivastigmine to prevent postoperative delirium in elderly patients undergoing elective cardiac surgery with cardiopulmonary bypass.

Cited by 231 publications

References 28 publications

Effect of melatonin on incidence of delirium among patients with hip fracture: a multicentre, double-blind randomized controlled trial

Effect of melatonin on incidence of delirium among patients with hip fracture: a multicentre, double-blind randomized controlled trial

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG2016)

Óráð eftir opna hjartaaðgerð: kerfisbundin samantekt á algengi, áhættuþáttum og afleiðingum

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