Rituximab Not Effective for Hearing Loss in Cogan’s Syndrome

Bunker, Daniel; Kerr, Leslie Dubin

doi:10.1155/2016/8352893

Cited by 2 publications

(2 citation statements)

References 15 publications

(17 reference statements)

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“…Adanya kondisi gagal respons dalam 2-3 minggu, ketidakmampuan untuk melakukan peningkatan dosis prednisone hingga 10 mg/hari secara bertahap atau terdapat toksisitas yang diinduksi glukokortikoid adalah indikasi penggunaan obat imunosupresif tambahan. 13,14,20 Obat imunosupresif yang telah digunakan termasuk methotrexate (15-25 mg/minggu), azathioprine (1,5-2,5 mg/kg/hari), siklofosfamid (2-3 mg/kg/hari PO), dan siklosporin A (5 mg/kg/hari). Obat-obat ini digunakan apabila terdapat kontra indikasi dalam pemberian kortikosteroid.…”

Section: Laporan Kasusunclassified

Case Report - Cogan Syndrome Atypical in Dr.Hasan Sadikin Hospital

Putra¹,

Mahdiani²,

Lasminingrum³

2022

J. Med. Health

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Cogan's syndrome is a rare autoimmune disorder with around 250 cases worldwide affecting young Caucasian adults in the third decade of life. This disease is characterized by audiovestibular disorders and inflammation in the eye. In this article, a case of Cogan's Syndrome was reported found in Dr. Hasan Sadikin Bandung ENT-HNS Clinic. Objective for this case report is as case study and knowledge because Cogan’s syndrome is a rare disease. Case: A 59-year-old woman with autoimmune disorders, interstitial keratitis in the eye and hearing loss in both ears, and without vestibular disorders. Audiogram examination revealed mild degree of sensorineural hearing loss in both ears. Patient is diagnosed with typical Cogan's Syndrome. Management of typical Cogan's Syndrome patients are the administration of methylprednisolone 48 mg per day; with a gradual reduction in dose; and prednisone eye drops, provides good response. Conclusion for this case report is Cogan’s syndrome are rare case and usually related with audiovestibular disorder and inflammation in the eye, management of Cogan's Syndrome with high doses of corticosteroids provides a good response.

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Section: Laporan Kasusunclassified

Case Report - Cogan Syndrome Atypical in Dr.Hasan Sadikin Hospital

Putra¹,

Mahdiani²,

Lasminingrum³

2022

J. Med. Health

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“…Among them, improvement in hearing loss was noted in only one patient [ 48 ]. Lack of efficacy was noted in a patient with atypical CS and non-Hodgkin's lymphoma [ 45 ] and in a patient with steroids and azathioprine-refractory CS [ 49 ].…”

Section: Biological Therapy In Cogan's Syndromementioning

confidence: 99%

Autoimmune Inner Ear Disease: Immune Biomarkers, Audiovestibular Aspects, and Therapeutic Modalities of Cogan’s Syndrome

Shamriz

Tal

Gross

2018

Journal of Immunology Research

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Cogan's syndrome (CS) is a rare autoimmune disorder characterized by audiovestibular dysfunction and ocular inflammation. Currently, there is no specific serum autoantibody used in the diagnostic workup of CS. Treatment is based on immunosuppressive agents, mainly corticosteroids as first-line choice. Recently, novel therapeutic modalities in CS have emerged. These include tumor necrosis factor-α inhibitors and other biologicals. Despite medical treatment, hearing loss may progress to irreversible bilateral profound SNHL in approximately half of CS patients resulting in candidacy for cochlear implantation (CI). Due to the inflammatory nature of the disease that is causing endosteal reaction with partial obliteration or complete neoossification of the intracochlear ducts, early CI is recommended. CI provides excellent and stable hearing rehabilitation with high score of word and sentence recognition. In this review, we will discuss different aspects of CS including clinical presentation, diagnosis, treatment, and future directives.

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Rituximab Not Effective for Hearing Loss in Cogan’s Syndrome

Cited by 2 publications

References 15 publications

Case Report - Cogan Syndrome Atypical in Dr.Hasan Sadikin Hospital

Case Report - Cogan Syndrome Atypical in Dr.Hasan Sadikin Hospital

Autoimmune Inner Ear Disease: Immune Biomarkers, Audiovestibular Aspects, and Therapeutic Modalities of Cogan’s Syndrome

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