Ritalin (Methylphenidate) Clinical Experiences

Perioperative Outcome of Dyssomnia Patients on Chronic Methylphenidate Use

“…The drug is known to affect arousal-associated pathways controlled by the neurotransmitters dopamine, norepinephrine, and histamine. 8 …”

“…The drug is known to affect arousal-associated pathways controlled by the neurotransmitters dopamine, norepinephrine, and histamine. 8 From the standpoint of anesthetic management and patient safety, the concerns for perioperative methylphenidate use are mainly related to cardiovascular stability and possible counteraction of sedatives and anesthetics. Methylphenidate and other amphetamine derivatives affect the release of endogenous catecholamines such as norepinephrine and dopamine, and thus act as indirect sympathomimetics.…”