Rita Levi-Montalcini: NGF, the prototypical growth factor

Zeliadt, Nicholette

doi:10.1073/pnas.1302413110

Cited by 7 publications

(4 citation statements)

References 16 publications

(15 reference statements)

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“…We predicted and analyzed the possible targeted genes of let-7d-5p, including OPRM1, NGF and NEDD4L. NGF, a protein that induces nerve growth, was first discovered 60 years ago by Rita Levi-Montalcini ( Zeliadt, 2013 ). Studies have found that NGF is also related to intractable pain ( Hirose et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Lung Cancer Cell-Derived Exosomal let-7d-5p Down-Regulates OPRM1 to Promote Cancer-Induced Bone Pain

Chen

Wang

et al. 2021

Front. Cell Dev. Biol.

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Cancer-induced bone pain (CIBP) is the pain caused by metastasis of malignant tumors to the bone, accounting for more than half of all chronic cancer pain, which seriously affects the quality of life among tumor patients. Up to 40% of patients with advanced lung cancer suffer from CIBP. MicroRNA (miRNA) transfers between cells through exosomes, mediates cell-to-cell communication, and performs various biological functions. Studies have shown that miRNAs secreted by cancer can modify the tumor microenvironment, but whether exosome-mediated miRNA transfer plays a role in CIBP is still unknown. In this study, the expression levels of 15 miRNAs in exosomes derived A549 cells and 18 miRNAs in exosomes derived NCI-H1299 cells were significantly up-regulated, and qRT-PCR further confirmed that the level of let-7d-5p was increased most considerably. In vitro, exosomal let-7d-5p (EXO let-7d-5p) can be taken up by dorsal root ganglion (DRG) neurons and inhibit the protein level of the target gene opioid receptor mu 1 (OPRM1). EXO let-7d-5p was further confirmed to be involved in the generation and maintenance of CIBP in vivo. Our findings clarify the molecular mechanism of CIBP caused by the inhibition of OPRM1 by EXO let-7d-5p, providing new clues and intervention targets for the prevention and treatment of CIBP.

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Section: Discussionmentioning

confidence: 99%

Lung Cancer Cell-Derived Exosomal let-7d-5p Down-Regulates OPRM1 to Promote Cancer-Induced Bone Pain

Chen

Wang

et al. 2021

Front. Cell Dev. Biol.

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“…Overall, evidence indicates that NGF is unable to generate cell carcinogenesis alone, both in normal neuronal and non-neuronal cells/tissues; however, it could be a major determinant in the case of co-expression with pro-carcinogenic molecules [74]. Quite intriguingly, NGF was initially discovered by R. Levi-Montalcini nearly 60 years ago in the context of a transplantation experiment involving a malignant mouse sarcoma [75,76].…”

Section: Role Of Ngf In Carcinogenesismentioning

confidence: 99%

Nerve Growth Factor and the Role of Inflammation in Tumor Development

Ferraguti,

Terracina,

Tarani

et al. 2024

CIMB

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Nerve growth factor (NGF) plays a dual role both in inflammatory states and cancer, acting both as a pro-inflammatory and oncogenic factor and as an anti-inflammatory and pro-apoptotic mediator in a context-dependent way based on the signaling networks and its interaction with diverse cellular components within the microenvironment. This report aims to provide a summary and subsequent review of the literature on the role of NGF in regulating the inflammatory microenvironment and tumor cell growth, survival, and death. The role of NGF in inflammation and tumorigenesis as a component of the inflammatory system, its interaction with the various components of the respective microenvironments, its ability to cause epigenetic changes, and its role in the treatment of cancer have been highlighted in this paper.

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“…Rita Levi-Montalcini was born on April 22, 1909 in Turin, Italy, and went on to make pivotal contributions to our understanding of neuroscience (Aloe, 2011). In 1947, Levi-Montalcini went to Washington University, in St. Louis, Missouri, to study nerve tissue growth in chick embryos in Viktor Hamburger's laboratory (Zeliadt, 2013). Hamburger and Levi-Montalcini discovered what they called nerve growth factor (NGF) (Aloe, 2011).…”

Section: Rita Levi-montalcinimentioning

confidence: 99%