Rita Levi-Montalcini: Neuroscientist par excellence

Iversen, Leslie L.

doi:10.1073/pnas.1301976110

Cited by 2 publications

(1 citation statement)

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“…The discovery of nerve growth factor (NGF) was not only one of the most important in neuroscience, but it involved a great story of courage and dedication. 35,36 NGF has multiple functions, but it is primarily a growth factor related to the peripheral sensory and sympathetic nervous systems. It was expected that there could be a large number of trophic factors in the CNS that would serve to both promote survival and guide neurons.…”

Section: Neurotrophinsmentioning

confidence: 99%

Motor Recovery: How Rehabilitation Techniques and Technologies Can Enhance Recovery and Neuroplasticity

Braun

Wittenberg

2021

Semin Neurol

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There are now a large number of technological and methodological approaches to the rehabilitation of motor function after stroke. It is important to employ these approaches in a manner that is tailored to specific patient impairments and desired functional outcomes, while avoiding the hype of overly broad or unsubstantiated claims for efficacy. Here we review the evidence for poststroke plasticity, including therapy-related plasticity and functional imaging data. Early demonstrations of remapping in somatomotor and somatosensory representations have been succeeded by findings of white matter plasticity and a focus on activity-dependent changes in neuronal properties and connections. The methods employed in neurorehabilitation have their roots in early understanding of neuronal circuitry and plasticity, and therapies involving large numbers of repetitions, such as robotic therapy and constraint-induced movement therapy (CIMT), change measurable nervous systems properties. Other methods that involve stimulation of brain and peripheral excitable structures have the potential to harness neuroplastic mechanisms, but remain experimental. Gaps in our understanding of the neural substrates targeted by neurorehabilitation technology and techniques remain, preventing their prescriptive application in individual patients as well as their general refinement. However, with ongoing research—facilitated in part by technologies that can capture quantitative information about motor performance—this gap is narrowing. These research approaches can improve efforts to attain the shared goal of better functional recovery after stroke.

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Section: Neurotrophinsmentioning

confidence: 99%