RISREAC Study: Assessment of Cutaneous Radiation Injury Through Clinical Documentation

Abstract

Objective: Radiation dermatitis (RD) occurs in 95% of patients receiving radiation therapy (RT) for cancer treatment, affecting 800 million patients annually. We aimed to demonstrate the feasibility of developing a historical RD cohort, Radiation Induced Skin Reactions (RISREAC) cohort. Methods: This retrospective study evaluated RD-related clinical documentation for 245 breast cancer patients who received RT at the University of Rochester Medical Center, to understand the RD progression, scoring, and management. All statistical analyses were performed at 0.05 level of significance. Results: Clinician-documented RD severity was observed for 169 (69%) patients with a mean severity of 1.57 [1.46, 1.68]. The mean descriptor-based severity score of 2.31 [2.18, 2.45] moderately correlated (r = 0.532, P < 0.0001) with documented RD grade. Most patients (91.8%) received skin care treatment during RT, with 66.7% receiving more than 2 modalities. Conclusions: The RISREAC cohort is the first retrospective cohort established from clinical documentation of radiation-induced skin changes for the study of RD and cutaneous radiation injury (CRI). RD symptom descriptors were more reliably documented and suitable for all skin types compared to Radiation Therapy Oncology Group (RTOG) or Common Toxicity Criteria for Adverse Events (CTCAE) grades. A new descriptor-based scoring tool would be useful for RD and CRI.

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“…The article brings up the importance of animal model selection when examining human medical countermeasure for sulfur mustard-induced skin injury. The article by Wolfe 7 focused on radiation dermatitis and gleaned knowledge gained from retrospective clinical studies of patients receiving radiation therapy and skin care treatments. The article discusses a novel descriptor-based scoring tool that could be useful in examining medical countermeasures for radiation-induced skin damage.…”