Risques pour la santé dans les laboratoires de recherche biologique et médicale : le point sur les connaissances épidémiologiques actuelles

Aj, Sasco

doi:10.4267/10608/4006

Cited by 6 publications

(6 citation statements)

References 3 publications

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“…The choice of the total French population as a reference was justified, since rare forms of cancer were involved. Nevertheless, our results are consistent with those of previous studies as regards the mortality from cancer among scientists potentially exposed to mixtures of chemicals, such as chemists or biologists (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). The statistical power of the study only allowed the detection of high risks.…”

Section: Discussionsupporting

confidence: 82%

“…The cases were all subjects identified as having had one of the following diagnoses: non- These types of cancer were chosen a priori as having been linked in some instances with the work environment of chemists and laboratory workers (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). Cases of decedents (N = 17) were identified from death certificates, and incident cases (N = 6) were gathered from the answers the questionnaire, or from occupational medical records for those who had a file in 1987 but had not answered the questionnaire.…”

Section: Nested Case-referent Studymentioning

confidence: 99%

“…These characteristics, combined with a very competitive work environment, explain why the objective surveillance of work conditions, essentially based on the degree of compliance to "good laboratory practices," is extremely difficult. Consequently, there is some apprehension about the effects of the aforementioned exposures on the health of laboratory workers (1).…”

mentioning

confidence: 99%

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Cancer risk among workers in biomedical research

Cordier¹,

Mousel²,

Goaster³

et al. 1995

Scand J Work Environ Health

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Objective This epidemiologic study was undertaken after a cluster of five cases of rare forms of cancer (bone sarcoma, non-Hodgkin's lymphoma) had been observed among biomedical research workers at the Pasteur Institute in Paris to ascertain whether their disease was connected with exposure during this research. Methods A mortality study included 3765 people who worked at the Pasteur Institute between 1971 and 1986 and were followed until the end of 1987. Within this cohort a nested case-referent study included 23 cases of cancer [non-Hodgkin's lymphoma (6), multiple myeloma (I), leukemia (3), pancreatic cancer (7), bone cancer (3), brain tumor (3)], and four referents per case, matched for gender and year of birth. Results Total mortality from cancer was less than expected, the standardized mortality ratio (SMR) being 72 for the men and 82 for the women. Among the women the proportion of pancreatic cancer cases was larger than expected [SMR 490, 95% confidence interval (95%CI) 158-1144], as was the number of brain cancer cases (SMR 239, 95% CI 48-696). Among the men, mortality from bone cancer was greater than expected (SMR 553,95% CI 62-2006). In the nested case-referent study, more cases than referents had worked in the areas of molecular biology [odds ratio (OR) 7.1, 95% CI 1.5-331 and microbial genetics (OR 6.7, 95% CI 1.3-35). These cases especially included non-Hodgkin's lymphoma and bone cancer. Associated with this finding was the fact that more cases had used certain chemicals, including ethidium bromide, acrylamide, methylnitronitrosoguanidine and ethylmethanesulfonate, and radioactive compounds (essentially 32phosphorus). C O~~C~U S~O~~S As the products used are potent genotoxicants, the present findings suggest that work in biomedical research might well involve an increased risk of certain types of cancer; this conclusion should be balanced by the fact that two of the five index cases were included in the mortality study and four in the nested casereferent study.

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Section: Discussionsupporting

confidence: 82%

Section: Nested Case-referent Studymentioning

confidence: 99%

mentioning

confidence: 99%

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Cancer risk among workers in biomedical research

Cordier¹,

Mousel²,

Goaster³

et al. 1995

Scand J Work Environ Health

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“…In addition to the fact that the long-term risks associated with biological research in laboratories have only relatively recently been evoked, the multiple exposures encountered today introduce an additional methodological dif®culty in the design and implementation of epidemiological studies. Although the toxicity and immediate risks resulting from the manipulation of certain substances are well known, the issue of occupational cancer risk for laboratory workers has only been quite recently explored [Sasco, 1989[Sasco, , 1992. Several studies have been motivated by the observation of cancer clusters [Pleven, 1984;Rutty et al, 1991] in various research institutes during the 1980s.…”

Section: Introductionmentioning

confidence: 99%

Cancer risk in laboratory workers: An emphasis on biological research

et al. 2000

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“…The environment in biomedical laboratories, with its special combination of several biological, chemical, and physical agents, is a potential risk for negative health effects [Sasco, 1989] and there is concern about this among the personnel. The work is associated with exposure to a mixture of known and potential chemical carcinogens, mutagens, and teratogens.…”

Section: Introductionmentioning

confidence: 99%

Mortality and cancer incidence in biomedical laboratory personnel in Sweden

et al. 1999

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Background: The work in biomedical laboratories is associated with exposure to a mixture of known and potential chemical carcinogens, mutagens, and teratogens. Previous studies have suggested an excess of brain tumors and hematopoietic system malignancies as well as breast cancers in women. Methods: This retrospective cohort study investigated the standardized mortality ratio (SMR) and the standardized incidence ratio (SIR) for cancer in biomedical research laboratory personnel in Swedish universities 1970–1992. The cohort comprised 5,035 laboratory and, as an internal reference group, 2,923 nonlaboratory employees. Results: The overall death rate was lower in both groups than in the general population. The SIR for brain tumors among male laboratory workers was 1.69 (0.62–3.68) and among male laboratory scientists, after more than 10 years of work (4 cases), it was 3.11 (0.85–7.56). There was an elevated SIR for malignant melanoma among female scientists in laboratories (3.51, 0.96–8.98) and for male scientists in nonlaboratory departments (2.86, 1.05–6.22). The SIR for breast cancer among female laboratory scientists was 1.62 (0.78–2.98). Conclusions: The present findings lend some support to an excess of brain tumors among male scientists and of breast cancer in female scientists in biomedical research laboratories. Am. J. Ind. Med. 35:382–389, 1999. © 1999 Wiley‐Liss, Inc.

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Risques pour la santé dans les laboratoires de recherche biologique et médicale : le point sur les connaissances épidémiologiques actuelles

Cited by 6 publications

References 3 publications

Cancer risk among workers in biomedical research

Cancer risk among workers in biomedical research

Cancer risk in laboratory workers: An emphasis on biological research

Mortality and cancer incidence in biomedical laboratory personnel in Sweden

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