Risques de morbidité maternelle et périnatale en fécondation in vitro : une étude nationale de cohorte française

Endometriosis and assisted reproductive techniques independently related to mother–child morbidities: a French longitudinal national study

“…KEYWORDS: endometriosis, assisted reproductive techniques, maternal and perinatal morbidity, pregnancy induced hypertension disorders, premature birth <A>Introduction Pregnancies achieved after assisted reproductive technologies (ART) are associated with increased risks of adverse obstetrical and perinatal outcomes compared with pregnancies that are spontaneously conceived (Qin et al, 2017;Pinborg, 2019h). Notably, significantly higher rates of maternal complications, such as gestational diabetes mellitus, venous thrombosis, gestational hypertensive disorders and perinatal complications (placenta previa, placental abruption, premature rupture of membranes, premature birth, postpartum haemorrhage) were reported after IVF and fresh embryo transfer compared with spontaneous conception (Lei et al, 2019;Pessione et al, 2020). Concerning neonatal effects, babies conceived after fresh IVF cycles have a significantly higher risk of preterm birth, low and very low birthweight, and neonatal morbidity compared with spontaneous conceptions (Koivurova et al, 2002;Pessione et al, 2020).…”

“…Notably, significantly higher rates of maternal complications, such as gestational diabetes mellitus, venous thrombosis, gestational hypertensive disorders and perinatal complications (placenta previa, placental abruption, premature rupture of membranes, premature birth, postpartum haemorrhage) were reported after IVF and fresh embryo transfer compared with spontaneous conception (Lei et al, 2019;Pessione et al, 2020). Concerning neonatal effects, babies conceived after fresh IVF cycles have a significantly higher risk of preterm birth, low and very low birthweight, and neonatal morbidity compared with spontaneous conceptions (Koivurova et al, 2002;Pessione et al, 2020). Moreover, children born after ART are at increased risk of birth defects (Hansen et al, 2005;Davies et al, 2012;Wen et al, 2012), and ART pregnancies have also been associated with higher rates of congenital anomalies, imprinting disorders and neurodevelopmental disorders (Strömberg et al, 2002;Lehti et al, 2013;Vermeiden and Bernardus, 2013).…”

Higher risk of pre-eclampsia and other vascular disorders with artificial cycle for frozen-thawed embryo transfer compared to ovulatory cycle or to fresh embryo transfer following in vitro fertilization

“…Assisted Reproductive Technologies (ART) have been associated to various maternal morbidities for which controlled ovarian stimulation regimens (9), embryo culture media (10,11), and/or subfertility in itself might play a role (12-14). Risks of maternal and perinatal morbidity (placenta previa, placental abruption, premature birth, small for gestational age, and perinatal mortality) are known to be reduced in pregnancies resulting from FET compared to fresh embryo transfer (fresh-ET), except for the risk of pre-eclampsia and severe pre-eclampsia that were reported to be significantly higher in pregnancies resulting from FET compared to fresh-ET or natural conception (9,(15)(16)(17)(18)(19)(20)(21). Gestational hypertension is a disease of pregnancy that combines an increase in blood pressure > 140 mmHg and/or 90 mmHg occurring after the 20th week of amenorrhea, measured twice, with or without proteinuria > 0.3g/24h and/or oedemas and clinical other symptoms (22).…”