Risques cardiovasculaires d’une corticothérapie

Szwebel, Tali‐Anne; Jeunne, Claire Le

doi:10.1016/j.lpm.2012.01.013

Cited by 5 publications

(1 citation statement)

References 61 publications

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“…But on the other hand, the hypertensive, hyperglycemic, and fat redistribution-promoting side effects of glucocorticoids may increase the atherosclerosis risk in RA patients. Some scholars have confirmed that although glucocorticoids can significantly relieve patient conditions, they can also significantly increase RA patients’ risk of atherosclerosis [ 31 , 32 ]. In addition, disease-modifying anti-rheumatic drugs represented by methotrexate, leflunomide, and hydroxychloroquine significantly improved and delayed the disease progression in RA patients [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Artery compliance in patients with rheumatoid arthritis: results from a case-control study

et al. 2017

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Atherosclerosis is one of the most common complications of rheumatoid arthritis (RA). The objective of this study is to evaluate differences in large artery compliance (C1) and small artery compliance (C2) between RA and controls and evaluating factors associated with reduced compliance in the RA population. The profiling of large and small arterial compliance was analyzed in 185 RA patients and 88 healthy controls using Cardiovascular Profiling Instrument. The correlations of arterial compliance and the relevant clinical data were determined in these subjects. Then correlation analysis and regression analysis were performed to find whether rheumatoid arthritis patients have more risk factors than healthy controls in artery compliance and to explore the possible element involved in RA patients including traditional cardiovascular risk factors, RA disease-related factors, and the therapy. Compared with healthy controls, levels of C1 and C2 were significantly decreased in RA patients. Having adjusted the traditional risk factors associated with atherosclerosis, C1 and C2 decline was still a significant indicator in RA patients [odds ratio = 7.411(95%CI 3.275, 16.771) and 10.184(95%CI 4.546, 22.817)]. Using multi-factor regression analysis to adjust traditional risk factors for arterial compliance, we found that the levels of ESR was correlated with the abnormal large artery compliance [odds ratio = 1.021(95%CI 1.007, 1.035)]. The HAQ values and the current usage of leflunomide were correlated with the abnormal small artery compliance in RA patients [odds ratio = 1.161(95%CI 1.046, 1.289) and 6.170(95%CI 1.510, 25.215)]. The values of C1 and C2 are indicators of artery compliance in RA patients. ESR, HAQ values, and the usage of leflunomide might be possible risk factors of artery compliance. The evaluation of artery compliance could be an easy and reliable test that could help us to screen and predict cardiovascular disorders in RA patients.Electronic supplementary materialThe online version of this article (10.1007/s10067-017-3899-8) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%