Risperidone: Treatment Response in Adult and Geriatric Patients

Abstract

Risperidone, at lower than recommended doses, shows promise in the treatment of late onset delusional disorders and behavior syndrome of dementia. The side effect profile was benign, as was suggested by experience in treating schizophrenia. Scientifically more rigorous prospective studies for the indications and efficacy of risperidone in late onset psychotic disorders and psychoses and behavior syndromes associated with dementing illness are overdue.

Older people with schizophrenia: a community study in a rural catchment area

“…We confirm previous findings that although both younger and older onset subjects had similar levels of symptomatology, the younger onset group required higher doses of medication (Graham et al, 2002;Kiraly et al, 1998). Rates of tardive dyskinesia were higher in the younger onset group.…”

The impact upon extra‐pyramidal side effects, clinical symptoms and quality of life of a switch from conventional to atypical antipsychotics (risperidone or olanzapine) in elderly patients with schizophrenia

“…However, these studies are imperfect for several reasons including: heterogeneous study population (Madhusoodanan et al, 1995;Joshi and Joshi, 1996;Davidson et al, 2000;Madhusoodanan et al, 2000), retrospective design (Kiraly et al, 1998;Madhusoodanan et al, 1999a;Solomon and Geiger, 2000) single arm (Madhusoodanan et al, 1995;Berman et al, 1996;Madhusoodanan et al, 1999b;Davidson et al, 2000;Madhusoodanan et al, 2000;Solomons and Geiger, 2000) small sample size (Madhusoodanan et al, 1995;Berman et al, 1996;Barak et al, 2001;Madhusoodanan et al, 2000) nonspecific or limited outcome measures (Kiraly et al, 1998) and short follow up period (Madhusoodanan et al, 1999b;Maguire et al, 2001;Jeste et al, 2001). Despite these limitations they have consistently indicated efficacy in improving core schizophrenic symptoms, reducing extra pyramidal side effects (EPSE) and being well tolerated.…”

The Role of Atypical Antipsychotic Agents in the Treatment of Schizophrenia and Schizoaffective Disorders in the Elderly

“…The literature on risperidone for the treatment of schizophrenia and related disorders in elderly patients includes a case series, seven retrospective studies (four retrospective comparison studies) ( Table 4), six open-label studies, and one double-blind comparison trial [45][46][47][48][49][50][51][52][53][54][55][56][57][58][59] (see Table 4). All published reports found a good-to-moderate response with risperidone.…”