Risperidone Related Raynaud's Phenomenon: An Adolescent Case

Güneş, Serkan; Ekinci, Özalp; Teke, Halenur; Yıldırım, Veli

doi:10.9758/cpn.2018.16.1.118

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…19 Triggers other than cold (eg, emotional stress), standardized questionnaires, photographs of episodes provided by patients, bilateral hand involvement even if asynchronous and asymmetrical, history of attacks at sites other than the hands, well demarcated medications, such as antimigraine drugs (ergot alkaloids), nonselective β -blockers, clonidine, psychostimulants (cocaine, amphetamine, methylphenidate), atomoxetine, risperidone, and aripiprazole are known to induce secondary RP. 10,11 Interferons, ribavirin, cyclosporine, chemotherapies (bleomycin, vinca alkaloids, gemcitabine, and cisplatin), and selective serotonin reuptake inhibitors (insufficient scientific evidence to be recommended in the treatment of RP) were also reported to be related with RP. 12 Furthermore, a recent analysis in the World Health Organization pharmacovigilance database VigiBase revealed a possible risk of RP with the use of proton pump inhibitors.…”

Section: Aspects Of Differential Diagnosismentioning

confidence: 99%

Recent advances in the workup and management of Raynaud’s phenomenon

Lis‐Święty

2019

Polish Archives of Internal Medicine

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oxide synthase 1 gene as significantly correlated with RP in the general population. 4 Major risk factors for primary RP include, in addition to the female sex and family history, a previous sensation of cold hands, migraine, cardiovascular diseases, decreased body mass index, manual occupation (not including vibration tool use), and estrogen replacement therapy. 3-6 Cigarette smoking and alcohol consumption are still of unclear significance when concerning the prevalence of primary RP. 7 Secondary RP associated with a known disease, mainly with systemic sclerosis (SSc) (>80% of patients) or other connective tissue diseases (CTDs), is rare and accounts for 10% to 20% of all RP cases. 8 Other common causes of secondary RP include diseases of arteries in the upper limbs (60% of RP occurring in individuals older than 60 years), malignancies, endocrine diseases, occupational syndromes, hematologic disorders, and infections (TABLE 1). 8,9 In addition, several Introduction Raynaud phenomenon (RP) is defined as recurrent, reversible episodes of vasospasm involving peripheral small vessels of the fingers and toes, at times also of the other acral sites (nose, ears, oral mucosa, lips, or nipples), when exposed to a cold environment or stressful situation. 1 This is characterized by a series of color changes in the affected area: first white (lack of blood flow), then bluish (deoxygenation of remaining blood), and red (reperfusion). Attacks can cause distal pain, burning, numbness, and paresthesia. 2 Regarding its etiology, RP is classified as primary (idiopathic) or secondary. Primary RP, which is an isolated finding without an underlying pathology, is common, occurring in about 5% of the general population living in areas with cold climates. 3 The prevalence of RP is higher in women (female-to-male ratio of 9 to 1). There is an associated genetic predisposition: one polymorphic variant was identified within the nitric

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Section: Aspects Of Differential Diagnosismentioning

confidence: 99%

Recent advances in the workup and management of Raynaud’s phenomenon

Lis‐Święty

2019

Polish Archives of Internal Medicine

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“…In recent years, it has been increasingly used in the treatment of various psychiatric disorders. 12,13 It is classified as an atypical antipsychotic and belongs to a new chemical class, namely benzisoxazole derivatives. Although risperidone has fewer extrapyramidal side effects than older neuroleptic drugs, it appears to have a greater potential to cause hyperprolactinemia.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory Thyroid Changes Following Serotonin Receptor Blocking in Experimental Rats

Dawood¹,

Aldabbagh²,

Alsarraf³

2023

Pharmacogn J.

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“…Recognizing that each medication has its own unique efficacy and side effects, some studies have questioned the usefulness of classifying antipsychotics as "atypical/ second-generation" rather than "first-generation" because more people use these medications. 11 It is argued that from a more nuanced perspective, it is preferable to match the requirements of unique patients with the characteristics of unique medications. Neuroleptic malignant syndrome, delayed dyskinesia (a severe movement disorder), increased risk of stroke, sudden cardiac death, blood clots, and diabetes are just some of the serious side effects of atypical antipsychotics, although they are generally considered safer than typical Pharmacognosy Journal, Vol 14, Issue 5, Sep-Oct, 2022 1.64.…”

Section: Introductionmentioning

confidence: 99%

Pathophysiological Electrolyte Changes Connoted via Antagonism of Serotonin Receptor in Experimental Animals

Mahmood¹,

Younes²,

Saarti³

2022

Pharmacogn J.

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Background: Atypical antipsychotics are a subclass of antipsychotics that have emerged primarily since the 1970s for the treatment of psychiatric disorders. They are sometimes referred to as second-generation antipsychotics (SGAs). Several atypical antipsychotics have received regulatory approval for the treatment of disorders such as bipolar disorder, schizophrenia, irritability in autism, and as adjunctive treatment for major depressive disorders. Objectives: The purpose of the following study was to evaluate the effect of two widely known atypical antipsychotics, aripiprazole, and risperidone, on pathophysiological fluctuations in electrolytes. Several other studies were based on the following ideas, which brought a variety of different perspectives. As can be seen in the following evaluation, although atypical antipsychotics reduce the chance of extrapyramidal symptoms, it leads to impairment of renal function and destruction of renal histo-morphology. Materials and Methods: Thirty rats (10 per group) were used for this study, control group received normal saline, aripiprazole group received 10mg/kg//day, and risperidone group received 20mg/kg//day. The duration of therapy was long up to 3 months. Results: the results confirmed that both drugs reduced plasma sodium and chloride concentration with no effects on plasma potassium and calcium concentration. Moreover, the histomorphology at microscopic level shown no defects after 3 months of therapy. Conclusion: the outcome confirmed no deleterious defects associated with aripiprazole and risperidone when used for 3 months.

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Risperidone Related Raynaud's Phenomenon: An Adolescent Case

Cited by 5 publications

References 16 publications

Recent advances in the workup and management of Raynaud’s phenomenon

Recent advances in the workup and management of Raynaud’s phenomenon

Inflammatory Thyroid Changes Following Serotonin Receptor Blocking in Experimental Rats

Pathophysiological Electrolyte Changes Connoted via Antagonism of Serotonin Receptor in Experimental Animals

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