Risky decision-making in major depressive disorder: A three-level meta-analysis

Lu, Jiaqi; Zhao, Xu; Wei, Xuxuan; He, Guibing

doi:10.1016/j.ijchp.2023.100417

Cited by 4 publications

(4 citation statements)

References 77 publications

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“…Contrary to previous reports of risk-aversion using BART in depression (33), we did not observe fewer balloon pumps among depression-only individuals. This discrepancy underscores the necessity of accounting for sample heterogeneity, given that NSSI was not examined in prior research on depression.…”

Section: Discussioncontrasting

confidence: 99%

“…Furthermore, the frequent comorbidity of NSSI with conditions like depression (29–31) adds another layer of complexity, potentially confounding the interpretation of the findings. Research on depression (often overlooking the comorbidity of NSSI) also have mixed findings: depressive moods are found to decrease individuals’ risk-aversion (32), but patients with depression may exhibit different risk preference in different risky decision tasks, such as lower risk-aversion in Iowa Gambling Task but higher risk-aversion in Balloon Analogue Risk Task (BART) (33). These limitations highlight the necessity of using more advanced methods to understand NSSI-related decision characteristics.…”

Section: Introductionmentioning

confidence: 99%

“…Our approach involved the use of the BART (34) alongside computational modeling to provide a comprehensive understanding of NSSI-related decision characteristics and their modulation by depression. The BART, which simulates real-world risk-taking behavior (33) by requiring participants to pump a virtual balloon for potential rewards, assesses not only attitudes toward risk or loss, as widely known, but also delves into broader cognitive dimensions. These include participants’ prior beliefs about risk, their learning from outcomes, and behavioral consistency under risk and uncertainty.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cognitive Phenotype Shifts in Risk-Taking: Interplay of Non-Suicidal Self-Injury Behaviors and Intensified Depression

Lu,

Ge,

et al. 2023

Preprint

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Non-suicidal self-injury (NSSI) behavior is significantly prevalent in both adolescents and psychiatric populations, with the highest risk observed in individuals with major depressive disorder (MDD). NSSI can be considered a result of risky decision-making in response to negative emotions, where individuals choose self-harm over other harmless alternatives, suggesting a potential decision-making deficit in NSSI individuals. This study delves into the complex relationship between NSSI and depression severity in decision-making and its cognitive underpinnings. We assessed decision behaviors in MDD patients with and without NSSI and healthy controls using the Balloon Analogue Risk Task, which involves risk-taking, learning, and exploration in uncertain scenarios. Using computational modeling, we dissected the nuanced cognitive dimensions influencing decision behaviors. A novel statistical method was developed to elucidate the interaction effects between NSSI and depression severity. Contrary to common perceptions, we found that individuals with NSSI behaviors were typically more risk-averse, but as depressive symptoms intensified, they began to perceive less risk and meanwhile behave more randomly. This research offers new insights into the cognitive aspects of NSSI and depression, underscoring the importance of recognizing the influence of comorbid mental disorders in deciphering the cognitive underpinnings of such behaviors, especially in the context of prevalent cross-diagnostic phenomena like NSSI behaviors.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cognitive Phenotype Shifts in Risk-Taking: Interplay of Non-Suicidal Self-Injury Behaviors and Intensified Depression

Lu,

Ge,

et al. 2023

Preprint

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“…Unexpectedly, lifetime suicide attempts, depression symptoms, and trait self-criticism were not associated with average IGT or CGT performance. Major depressive disorder is associated with lower net scores (more risky decision-making) on the classic IGT (101), but results for the effect of depression symptoms are more mixed (e.g., 34,[102][103][104].…”

Section: Rival Clinical Predictorsmentioning

confidence: 98%

Risky decision-making and nonsuicidal self-injury among university students: Examining the role of criticism feedback

Nancekivell,

Martin,

Jacobson

et al. 2024

Preprint

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Risky decision-making putatively contributes to nonsuicidal self-injury (NSSI) yet empirical support for this association is inconsistent. Studies have not simulated socioemotional contexts most closely linked to NSSI, which may partially explain mixed findings. Accordingly, we examined the association between NSSI and risky decision-making following the receipt of criticism from a close other, a key interpersonal context. The study included 286 university students (Mage = 21.11) oversampled for a lifetime history of NSSI. Participants completed a modified Iowa Gambling Task, in which they chose to play or pass on “good” and “bad” decks associated with monetary gains and losses. Participants also completed the Criticism Gambling Task, which was identical to the Iowa Gambling Task except critical audio comments preceded each block of trials. Based on results of multilevel growth curve analyses, decreases in risky decision-making were steeper on the Iowa Gambling Task compared to the Criticism Gambling Task, suggesting poorer learning in the context of criticism. Further, how past-month NSSI was related to changes in risky decision-making across blocks differed between the two tasks, b = -0.004, t(3140.00) = 2.48, p = .013. On the Iowa Gambling Task, all participants decreased their risky decision-making; whereas on the Criticism Gambling Task, higher past-month NSSI frequencies were associated with riskier decision-making. Our findings support associations between risky decision-making and NSSI in negative socioemotional contexts, consistent with functional models of NSSI.

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Cognitive Phenotype Shifts in Risk Taking: Interplay of Nonsuicidal Self-Injury Behaviors and Intensified Depression

Lu,

Ge,

et al. 2024

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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Risky decision-making in major depressive disorder: A three-level meta-analysis

Cited by 4 publications

References 77 publications

Cognitive Phenotype Shifts in Risk-Taking: Interplay of Non-Suicidal Self-Injury Behaviors and Intensified Depression

Cognitive Phenotype Shifts in Risk-Taking: Interplay of Non-Suicidal Self-Injury Behaviors and Intensified Depression

Risky decision-making and nonsuicidal self-injury among university students: Examining the role of criticism feedback

Cognitive Phenotype Shifts in Risk Taking: Interplay of Nonsuicidal Self-Injury Behaviors and Intensified Depression

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