Risks of venous thromboembolism in patients with liver cirrhosis: a nationwide cohort study in Taiwan

Ng, Kenney; Lee, Y.-K.; Huang, Ming-Yuan; Hsu, Chin-Hsien; Su, Yu‐Chieh

doi:10.1111/jth.12805

Cited by 42 publications

(55 citation statements)

References 23 publications

(35 reference statements)

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“…Previous studies validated these selection procedures and definitions, with high positive predictive values [18,19]. …”

Section: Methodsmentioning

confidence: 99%

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Association between Chronic Kidney Disease and Risk of Cataract: A Nationwide Retrospective Cohort Study

Liu

Hung²,

Lee³

et al. 2017

Am J Nephrol

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Background: Previous studies have established a relationship between chronic kidney disease (CKD) and cataract, but the relationship between the severity of renal impairment and risk of cataract is uncertain. This study investigates the relationship between the severity of renal disease and cataract in a nationwide sample from Taiwan. Methods: The cohort from 1-million National Health Insurance beneficiaries from Taiwan was retrospectively analyzed. All adult beneficiaries were followed from January 1, 2005 until December 31, 2013, to identify patients who underwent cataract surgeries. On the basis of the ambulatory care records, those diagnosed with CKD (ICD-9-CM code: 585) during the follow-up period were enrolled as CKD patients after careful evaluation. Each patient with CKD was age- and gender-matched with 4 individuals who did not have CKD. Cox regression models were applied to compare the hazard of cataract surgery in individuals with and without CKD. Subgroup analysis was used to compare patients with end-stage renal disease (ESRD) with age- and gender-matched non-CKD individuals. ESRD was defined by CKD patients who need regular renal replacement therapy. The same method was applied to evaluate hazard ratios (HRs). Results: After age and gender matching, there were 11,881 patients in the CKD group and 47,524 in the non-CKD group. After control for possible confounding, the adjusted HR (aHR) of cataract was 1.84 (95% CI 1.73-1.95) for the CKD group. Subgroup analysis of patients with ESRD (n = 3,209) and non-CKD individuals (n = 12,836), with matching done on the basis of age and gender, indicated an aHR of cataract was 2.33 (95% CI 2.10-2.59) for the ESRD group. Conclusions: This study indicates a relationship between CKD and cataract, and suggests that the risk for cataract increases with the severity of renal impairment.

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“…Previous studies validated these selection procedures and definitions, with high positive predictive values [18,19]. …”

Section: Methodsmentioning

confidence: 99%

“…The detailed ICD-9-CM codes for comorbidities are described elsewhere, and the processes used for selecting comorbidities are standard and widely accepted [19,21,22]. …”

Section: Methodsmentioning

confidence: 99%

Association between Chronic Kidney Disease and Risk of Cataract: A Nationwide Retrospective Cohort Study

Liu

Hung²,

Lee³

et al. 2017

Am J Nephrol

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“…These selection processes have been well-validated with high positive predictive values. 4,23 After excluding patients with diabetes and AP before January 1, 2005, 42,080 patients were included in the diabetic group and 672,146 in the unexposed group. Diabetes with poor compliance was defined as a hospitalization with the diagnosis of a hyperglycemic crisis episode (HCE) (ICD-9-CM codes: diabetic ketoacidosis, 250.1 or hyperosmolar hyperglycemic state, 250.2).…”

Section: Analysis Of the Association Between Diabetes And Risk Of Acumentioning

confidence: 99%

“…The detailed ICD-9-CM codes for comorbidities are described elsewhere, and the processes for selecting comorbidities are widely used and accepted. 4,18,23,25 Statistical Analysis…”

Section: Covariatesmentioning

confidence: 99%

“…However, the definitions of exposures and outcomes in this study are wellaccepted in the administrative database, and previous studies focusing on either AP or diabetes and using similar enrollment criteria from the same database revealed good validities. 4,23,38,39 Second, laboratory findings relevant to the severity of diabetes, including HbA1c and blood glucose values, were unavailable in the database. Alternatively, since uncontrolled diabetes is the most common factor precipitating HCE, 24 diabetes with poor compliance was defined as diabetes with at least one episode of HCE.…”

Section: Limitationsmentioning

confidence: 99%

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330 Bidirectional Relationship Between Diabetes and Acute Pancreatitis: A Population-Based Cohort Study in Taiwan

Su¹

2015

Annals of Emergency Medicine

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The proposed bidirectional relationship between acute pancreatitis (AP) and diabetes has never been examined with the same source of data. Furthermore, the effects of disease severity on this relationship have not been fully evaluated. The present study employed the findings from a single database to measure the strength of the association between AP and diabetes.Findings from 1 million National Health Insurance beneficiaries were utilized. Two cohort studies with this database were selected to evaluate the linkage between diabetes and AP. The first cohort analysis addressed the risk of AP among diabetic patients and was comprised of 42,080 diabetic patients and 672,146 unexposed subjects. The second cohort analysis considered the risk of diabetes among patients with AP and enrolled 3187 patients with AP and 709259 unexposed subjects. All adult beneficiaries were followed from January 1, 2005 to December 31, 2012 to identify outcomes of interest. Cox regression models were applied to compare hazards adjusted for potential confounders.For the first cohort, the adjusted hazard ratio (HR) of AP was significantly increased by the presence of diabetes (1.72; 95% confidence interval [CI], 1.52-1.96). In diabetic patients with a history of hyperglycemic crisis episodes (HCEs), the HR was even higher (6.32; 95% CI, 4.54-8.81). For the second cohort, the adjusted HR of diabetes in patients with AP was increased compared to the general population (2.15; 95% CI, 1.92-2.41). For patients with severe AP, the HR was also higher (2.22; 95% CI, 1.50-3.29) but did not differ significantly from that for patients with nonsevere AP.The 2 cohort studies provided evidence for the bidirectional relationship between diabetes and AP. Moreover, diabetic patients with history of HCEs may be associated with higher risk of AP.

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Risk of Venous Thromboembolism Among Adults With Atopic Dermatitis

et al. 2023

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ImportanceThe associations of atopic dermatitis (AD) with multiple cardiovascular comorbidities have been investigated because of its pathomechanisms regarding chronic systemic inflammation and potential vascular effects. Nevertheless, the association between AD and incident venous thromboembolism (VTE) in adulthood is largely unknown. This study aimed to investigate the association of AD with incident VTE.ObjectiveTo examine the risk of incident VTE among patients with AD.Design, Setting, and ParticipantsThis population-based nationwide cohort study included adults 20 years or older (adults with AD newly diagnosed between 2003 and 2017 and matched controls) from the National Health Insurance Research Database. Patients with AD were subgrouped according to the severity of the disease. A Cox regression model was used to estimate hazard ratios (HRs) for VTE. Stratified analyses according to age and sex, and a sensitivity analysis excluding systemic steroid users were performed.Main Outcomes and MeasuresHazard ratios (HRs) for incident VTE associated with AD.ResultsThis analysis included a total of 284 858 participants, with 142 429 participants each in the AD (mean [SD] age, 44.9 [18.3] years; 78 213 women) and non-AD cohorts (mean [SD] age, 44.1 [18.1] years; 79 636 women). During the follow-up, 1066 patients (0.7%) in the AD cohort and 829 patients (0.6%) in the non-AD cohort developed VTE, with incidence rates of 1.05 and 0.82 per 1000 person-years, respectively. Adults with AD had a significantly increased risk of incident VTE (HR, 1.28; 95% CI, 1.17-1.40) compared with adults without AD. Individual outcome analyses suggested that AD was associated with higher risks of deep vein thrombosis (HR, 1.26; 95% CI, 1.14-1.40) and pulmonary embolism (HR, 1.30; 95% CI, 1.08-1.57).Conclusions and RelevanceThe results of this cohort study suggest that AD in adulthood is associated with an increased risk of VTE; however, the absolute risk difference of VTE between adults with and without AD appears small. Nevertheless, cardiovascular examination and imperative management may be considered for adults with AD who present with symptoms suggestive of VTE. Future research is warranted to elucidate the pathophysiology underlying the association between AD and VTE.

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Risks of venous thromboembolism in patients with liver cirrhosis: a nationwide cohort study in Taiwan

Cited by 42 publications

References 23 publications

Association between Chronic Kidney Disease and Risk of Cataract: A Nationwide Retrospective Cohort Study

Association between Chronic Kidney Disease and Risk of Cataract: A Nationwide Retrospective Cohort Study

330 Bidirectional Relationship Between Diabetes and Acute Pancreatitis: A Population-Based Cohort Study in Taiwan

Risk of Venous Thromboembolism Among Adults With Atopic Dermatitis

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