2019
DOI: 10.1136/bmjopen-2019-032711
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Risks of psychosis in methamphetamine users: cross-sectional study in Thailand

Abstract: ObjectiveTo determine factors related to recent methamphetamine-associated psychosis (MAP) among individuals recently using methamphetamine (MA).DesignCross-sectional study carried out between July 2015 and June 2017.SettingFour mental health hospitals and one substance abuse treatment centre in Thailand.ParticipantsIndividuals recruited onto the study included those aged 18 years or over, of both sexes, who reported MA use in the month prior to admission.MeasuresAny recent psychosis was confirmed using the Mi… Show more

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Cited by 15 publications
(7 citation statements)
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“…They found evidence that greater odds of psychotic symptoms were associated with more frequent MA use, the quantity of MA used, greater severity of MA addiction, and polydrug use. These results were later confirmed by other Authors, and MIP was associated with: earlier onset of drug use ( 27 , 106 108 ), longer duration of MA use ( 26 ), higher MA use dose ( 26 , 27 ), greater severity of MA addiction ( 27 , 107 , 108 ), polydrug use ( 26 ) nature of MA use (crystal methamphetamine vs. other forms of methamphetamine) ( 109 ) and comorbid depression or anxiety symptoms ( 26 , 27 , 108 ). Examining the prospective relationship between the duration of MA use and psychotic symptoms, it was found that the risk of experiencing psychotic symptoms was higher during periods of MA use compared with no use and, as the duration of MA exposure increased, the odds of experiencing psychotic symptoms also increased, with a clear dose-response effect of continued MA use on the risk of psychotic symptoms ( 110 ).…”
Section: Resultssupporting
confidence: 81%
See 1 more Smart Citation
“…They found evidence that greater odds of psychotic symptoms were associated with more frequent MA use, the quantity of MA used, greater severity of MA addiction, and polydrug use. These results were later confirmed by other Authors, and MIP was associated with: earlier onset of drug use ( 27 , 106 108 ), longer duration of MA use ( 26 ), higher MA use dose ( 26 , 27 ), greater severity of MA addiction ( 27 , 107 , 108 ), polydrug use ( 26 ) nature of MA use (crystal methamphetamine vs. other forms of methamphetamine) ( 109 ) and comorbid depression or anxiety symptoms ( 26 , 27 , 108 ). Examining the prospective relationship between the duration of MA use and psychotic symptoms, it was found that the risk of experiencing psychotic symptoms was higher during periods of MA use compared with no use and, as the duration of MA exposure increased, the odds of experiencing psychotic symptoms also increased, with a clear dose-response effect of continued MA use on the risk of psychotic symptoms ( 110 ).…”
Section: Resultssupporting
confidence: 81%
“…Examining the prospective relationship between the duration of MA use and psychotic symptoms, it was found that the risk of experiencing psychotic symptoms was higher during periods of MA use compared with no use and, as the duration of MA exposure increased, the odds of experiencing psychotic symptoms also increased, with a clear dose-response effect of continued MA use on the risk of psychotic symptoms ( 110 ). Nie et al ( 106 ), conversely, reported a negative association between the development of psychotic symptoms and higher dose of MA use, suggesting protection through tolerance, while Lamyai et al ( 107 ) stated that the amount of MA use measured by hair analysis was not related to the experience of MA psychosis.…”
Section: Resultsmentioning
confidence: 99%
“…The proportion of psychiatric symptoms arising from MA use can differ in other populations. Different patterns of MA use and concomitant narcotic use may contribute to the differences between populations [13][14][15].…”
Section: Discussionmentioning
confidence: 99%
“…Antisocial personality may be related with withdrawal symptoms because it increases the risk of long-term MA use (64) . Alcohol or nicotine use are very common in Thai individuals with heavy MA use increasing the risk of withdrawal symptoms when they stop using MA (66,67) .…”
Section: Discussionmentioning
confidence: 99%