Risks of Propofol Sedation/Anesthesia for Imaging Studies in Pediatric Research

Kiringoda, Ruwan; Thurm, Audrey; Hirschtritt, Matthew E.; Koziol, Deloris E.; Wesley, Robert; Swedo, Susan E.; O’Grady, Naomi P.; Quezado, Zenaide M.N.

doi:10.1001/archpediatrics.2010.75

Cited by 39 publications

(26 citation statements)

References 27 publications

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“…Sample size was estimated a priori using the following assumptions based on our clinical experience of adverse airway events with both techniques and the available literature [16][17][18] : α 2 0.05, β 0.2, a 30% incidence of adverse airway events in the children anesthetized with isoflurane/N 2 O, 16 and a 10% incidence in those anesthetized with propofol. 17,18 These assumptions yielded a sample size of 72 children in each group.…”

Section: Discussionmentioning

confidence: 99%

“…17,18 These assumptions yielded a sample size of 72 children in each group. To account for study failures and dropouts, 75 children were enrolled in each group.…”

Section: Discussionmentioning

confidence: 99%

“…However, the frequency of adverse airway events is consistent with those reported for the 2 anesthetics. 2,16,17,19 In the case of propofol with nasal cannula, avoiding a supraglottic airway may reduce the frequency of upper airway adverse events. Furthermore, in a model of upper airway irritability using saline to trigger apnea and laryngospasm, the incidence of acute airway responses during propofol anesthesia was significantly less than during sevoflurane anesthesia, independent of the depth of anesthesia.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Propofol Anesthesia for Children Undergoing Magnetic Resonance Imaging

Heard¹,

Harutunians²,

Houck³

et al. 2015

Anesthesia &Amp; Analgesia

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Section: Discussionmentioning

confidence: 99%

“…17,18 These assumptions yielded a sample size of 72 children in each group. To account for study failures and dropouts, 75 children were enrolled in each group.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Propofol Anesthesia for Children Undergoing Magnetic Resonance Imaging

Heard¹,

Harutunians²,

Houck³

et al. 2015

Anesthesia &Amp; Analgesia

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“…Propofol and fentanyl are the most effective drugs for deep S/GA, but the risk of requiring advanced airway management is high [43]. Kiringoda et al [44] confirmed in a retrospective study a low incidence of adverse events and no long-term complications in highrisk children (ASA Class 3) who received propofol S/GA (PSA) by an anaesthesiologist for research-related imaging studies.…”

Section: Intravenous Anaestheticsmentioning

confidence: 99%

Sedation/anaesthesia in paediatric radiology

Arlachov¹,

Ganatra²

2012

The British Journal of Radiology

126

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Objectives In this article we will give a comprehensive literature review on sedation/general anaesthesia (S/GA) and discuss the international variations in practice and options available for S/GA for imaging children. Methods The key articles were obtained primarily from PubMed, MEDLINE, ERIC, NHS Evidence and The Cochrane Library. Results Recently, paediatric radiology has seen a surge of diagnostic and therapeutic procedures, some of which require children to be still and compliant for up to 1 h. It is difficult and sometimes even impossible to obtain quick and high-quality images without employing sedating techniques in certain children. As with any medical procedure, S/GA in radiological practice is not without risks and can have potentially disastrous consequences if mismanaged. In order to reduce any complications and practice safety in radiological units, it is imperative to carry out pre-sedation assessments of children, obtain parental/guardian consent, monitor them closely before, during and after the procedure and have adequate equipment, a safe environment and a well-trained personnel. Conclusion Although the S/GA techniques, sedative drugs and personnel involved vary from country to country, the ultimate goal of S/GA in radiology remains the same; namely, to provide safety and comfort for the patients. Advances in knowledge Imaging children under general anaesthesia is becoming routine and preferred by operators because it ensures patient conformity and provides a more controlled environment.

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“…Propofol may shorten seizure duration [15]. It was reported to shorten seizure duration by up to 38.7% and has been safely used in adults and adolescents, particularly in cases where prolonged seizures are feared [61,62]. A switch from methohexital to propofol has been helpful in reducing post-treatment nausea and vomiting [61].…”

Section: Ect Administrationmentioning

confidence: 99%

Electroconvulsive therapy in children and adolescents

Shoirah¹,

Hamoda

2011

Expert Review of Neurotherapeutics

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Electroconvulsive therapy (ECT) is a recognized and effective treatment in adults for several psychiatric and neurological conditions in which the use of pharmacotherapy is ineffective, untimely or contraindicated. It has been used with success in mood and psychotic disorders, catatonia, neuroleptic malignant syndrome, Parkinson's disease and intractable seizures. Its benefits have been recognized and its risks identified through an extensive body of research. The benefits of ECT are not limited to the adult population; research has been conducted on its use in child and adolescent populations for decades. In 2004, the American Academy of Child and Adolescent Psychiatry published practice parameters for the use of ECT in adolescent populations. However, ECT continues to be underused in cases where it is clearly indicated. In this article, we review the use of ECT in the adolescent population; its indications, administration, contraindications and risks, with emphasis on articles published after the American Academy of Child and Adolescent Psychiatry practice parameters were formulated. We also review reasons behind the underutilization of ECT in adolescents for whom this treatment modality is indicated.

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Risks of Propofol Sedation/Anesthesia for Imaging Studies in Pediatric Research

Cited by 39 publications

References 27 publications

Propofol Anesthesia for Children Undergoing Magnetic Resonance Imaging

Propofol Anesthesia for Children Undergoing Magnetic Resonance Imaging

Sedation/anaesthesia in paediatric radiology

Electroconvulsive therapy in children and adolescents

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