Risks of Immunosuppressive Therapy in Patients Undergoing Open Reduction Internal Fixation for Ankle Fractures

Effects of Preoperative Chronic Steroid Use on Postoperative Outcomes in Orthopedic Surgery: A Systematic Review and Meta-Analysis

“…Among the included studies, the patients classified as preoperative chronic steroid users mostly met the following criteria: patients required regular oral or parental corticosteroid medications for chronic conditions within 30 days prior to the index surgical procedures or being a surgical candidate [ 12 , 13 , 14 , 15 , 19 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 30 , 31 ]. Patients taking a limited short course (≤10 days) or taking topical, inhaled, and rectal steroids were excluded.…”

“…The outcomes of interest included mortality, overall complications, wound dehiscence, infectious complications, thromboembolism, re-admission, and re-operation. Most studies reported whether these outcomes occurred within 30 days after the index surgical procedures [ 12 , 13 , 14 , 15 , 19 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 30 , 31 ]. Some studies provided outcome data at different time points.…”

“… Adjusted odds ratios of 30-day mortality, overall complications, wound dehiscence, re-admission, and both 30-day and 1-year re-operation [ 12 , 15 , 19 , 20 , 22 , 25 , 27 , 28 , 31 ]. …”

“…No statistical heterogeneity was detected across these studies (I 2 = 0%). [12][13][14]19,22,25,30]. Figure 3.…”

“…24-3.46) were detected in patients with preoperative chronic steroid use (Figure 4). [14,19,20,22,25,31].…”