Risks of exposure to X-rays in patients undergoing long-term treatment for scoliosis.

Nash, Clyde L.; Gregg, Earle C.; Brown, Robert H.; Pillai, Kamala

doi:10.2106/00004623-197961030-00009

Cited by 150 publications

(82 citation statements)

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“…The mean estimated cumulative dose to the breast ranges from 0.3 to 10.9 cGy [13,14], leading to a relative risk of breast cancer mortality that was found to be significantly increased in previous studies, using systems not allowing dose reduction. The potential risk of multiple radiographic examinations especially in the management of scoliosis, has led to efforts to reduce patient exposure on the basis of the ALARA principles [1,3,12,15]. This includes using postero-anterior instead of antero-posterior exposure to limit mammary exposure, limiting the number of radiographs (only frontal view in the follow-up), and development of competing digital technologies.…”

Section: Discussionmentioning

confidence: 99%

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Radiography of scoliosis: Comparative dose levels and image quality between a dynamic flat-panel detector and a slot-scanning device (EOS system)

Yvert

Diallo

Bessou

et al. 2015

Diagnostic and Interventional Imaging

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Section: Discussionmentioning

confidence: 99%

“…Therefore, the most radiosensitive organs such as thyroid gland, mammary glands or gonads are exposed during repeated radiographic examinations, resulting in high-cumulated effective doses [1]. The risks of radiation-induced side effects have been widely discussed in the literature in recent years, especially the possible induction of cancer in children [2,3].…”

mentioning

confidence: 99%

Radiography of scoliosis: Comparative dose levels and image quality between a dynamic flat-panel detector and a slot-scanning device (EOS system)

Yvert

Diallo

Bessou

et al. 2015

Diagnostic and Interventional Imaging

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show abstract

“…The lifetime risk of cancer from spinal radiographs for patients with AIS cannot be neglected [6,8]. Progression of deformity is generally expressed by an increased Cobb-angle [7].…”

Section: Torsten Kluba Ju¨rgen Scha¨fer Tobias Hahnfeldt Thomas Niemeyermentioning

confidence: 99%

Prospective randomized comparison of radiation exposure from full spine radiographs obtained in three different techniques

et al. 2006

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“…Nevertheless, wearing brace is always associated with excessive radiographic exposure, anxiety and indirect costof-care caused by absence from work or travel expenses [4,5]. An investigation into the factors that affect the outcome of brace treatment could help narrow the field of indications and provide further insight into whether brace treatment should be continued so as to avoid overtreatment or not.…”

Section: Introductionmentioning

confidence: 99%

Potential genetic markers predicting the outcome of brace treatment in patients with adolescent idiopathic scoliosis

Qiu

Sun

et al. 2011

Eur Spine J

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Purpose To investigate whether the predisposition genes previously reported to be associated with the occurrence or curve severity of adolescent idiopathic scoliosis (AIS) play a role in the effectiveness of brace treatment. Method A total of 312 AIS patients treated with bracing were enrolled in this study. The Cobb angle of the main curve was recorded at the beginning of brace treatment as well as at each follow-up. The patients were divided into two groups according to the outcome of brace treatment (success/failure). The failure of brace treatment was defined as a curve progression of more than 5°compared to the initial Cobb angle or surgical intervention because of curve progression. Single nucleotide polymorphism (SNP) sites in the genes for estrogen receptor a (ERa), estrogen receptor b (ERb), tryptophan hydroxylase 1 (TPH-1), melatonin receptor 1B (MTNR1B) and matrillin-1 (MATN1), which were previously identified to be predisposition genes for AIS, were selected for genotyping by the PCR-RFLP method. Differences of genotype and allele distribution between the two groups were compared by the v 2 test. A logistic regression analysis was used to figure out the independent predictors of the outcome of brace treatment. Results There were 90 cases (28.8%) in the failure group and 222 cases (71.2%) in the success group. Patients in the failure group were associated with the genotype GA (50.9 vs. 17.9% p \ 0.001) and the G allele (27.1 vs. 12.0%, p \ 0.001) at SNP rs9340799 of the ERa gene. Similarly, they were also associated with the genotype AT (33.3 vs.13.0%, p = 0.002) and the A allele (16.7 vs. 9.6%, p = 0.033) at SNP rs10488682 of the TPH-1 gene. For MTNR1B, the difference of genotype distribution between the two groups was found to be statistically significant, while the difference of allele distribution between the two groups was found to be marginally statistically significant; for the MATN1 and ERb genes, we found no significant differences of the genotype or allele distribution between the two groups. In the logistic regression analysis, ERa and TPH-1 were demonstrated to be independent factors predictive of bracing effectiveness. Conclusions ERa and TPH-1 might be potential genetic markers that could predict the outcome of brace treatment. Patients with the G allele at the rs9340799 site of the ERa gene and the A allele at the rs10488682 site of the TPH-1 gene are prone to be resistant to brace treatment.

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Risks of exposure to X-rays in patients undergoing long-term treatment for scoliosis.

Cited by 150 publications

References 0 publications

Radiography of scoliosis: Comparative dose levels and image quality between a dynamic flat-panel detector and a slot-scanning device (EOS system)

Radiography of scoliosis: Comparative dose levels and image quality between a dynamic flat-panel detector and a slot-scanning device (EOS system)

Prospective randomized comparison of radiation exposure from full spine radiographs obtained in three different techniques

Potential genetic markers predicting the outcome of brace treatment in patients with adolescent idiopathic scoliosis

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