Risks of ACTH therapy for West syndrome following BCG vaccination

Maki, Yuki; Natsume, Jun; Hori, Ikumi; Takeuchi, T. T.; Negishi, Yutaka; Maruyama, Koichi; Nakata, T.; Yamamoto, Hiroyuki; Tanaka, Masaharu; Kawaguchi, Masahiro; Suzuki, Takeshi; Shiraki, Anna; Sawamura, Fumi; Kidokoro, Hiroyuki

doi:10.1016/j.yebeh.2021.107924

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…Previous studies have suggested that the immunosuppression induced by corticotropic hormone (ACTH) following treatment of epilepsy may contribute to BCG infection. 12 But no one has reported that BCG can directly cause seizures. In this case, the infant got the BCG vaccine at birth and developed 3 convulsions within 48 hours after the vaccination.…”

Section: Discussionmentioning

confidence: 99%

First vaccination after birth: serious adverse events of Bacillus Calmette-Guérin (BCG) in real-world

Zhang

et al. 2022

Human Vaccines & Immunotherapeutics

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The Bacillus Calmette-Guérin (BCG) vaccine is a free vaccine in China, and more than 300 million newborns have been vaccinated. Inevitably, the BCG vaccine will have some rare adverse events on the first day of life (24 hours after birth), but related reports are extremely rare. In this commentary, the authors searched the Chinese legal documents database for documents related to serious adverse events caused by BCG from January 2010 to January 2022. Fourteen pediatric cases were identified, including 7 preterm infants and 7 full-term infants. The events included 4 cases of interstitial pneumonia, 3 cases of lymphadenitis, 3 cases of septicemia, 1 case of myocarditis, 1 case of muscle atrophy, 1 case of epilepsy, and 1 case of disseminated BCG vaccine. The mortality rate of preterm infants was 100% and that of full-term infants was 28.6% (2/7). All deaths occurred within one day. The BCG vaccine has good safety for the vast majority of newborns.

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Section: Discussionmentioning

confidence: 99%

First vaccination after birth: serious adverse events of Bacillus Calmette-Guérin (BCG) in real-world

Zhang

et al. 2022

Human Vaccines & Immunotherapeutics

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“…The interval between the administration of hormone therapy and vaccination was very short, almost 14 days. The evidence showed that none of the patients developed a BCG infection, even up to an interval of eight weeks there was no development of an infection (9).…”

Section: Introductionmentioning

confidence: 92%

West Syndrome, Updated Information From 2021 Until 2022

García¹,

Calderón²,

Belesaca³

et al. 2022

EPRA

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Congenital Zika infection has been linked to phenotypic features including neurological sequelae. In relation to West syndrome, it has been shown that of 147 children with congenital Zika infection, 7.5% suffer from West syndrome. Furthermore, in the management of this syndrome, the use of vigabatrin has been shown to be an appropriate therapy for these patients (1). This is one of the studies with which we want to demonstrate the variations in the current treatment of West syndrome. The aim of this literature review is to demonstrate how varied the treatment of this pathology is so far, to show what the medical literature says about the most adequate treatment in the last 2 years. KEYWORDS: Nervous System, West Syndrome, Infantile Spasms

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Risks of ACTH therapy for West syndrome following BCG vaccination

Cited by 2 publications

References 22 publications

First vaccination after birth: serious adverse events of Bacillus Calmette-Guérin (BCG) in real-world

First vaccination after birth: serious adverse events of Bacillus Calmette-Guérin (BCG) in real-world

West Syndrome, Updated Information From 2021 Until 2022

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