“…Also, the tendency to higher density production systems, the perturbations in ecological systems balance related to pollution and climatic changes, and the expected increase in international transactions of aquaculture products and their derivatives contributed to alterations on the dynamics of interaction between organisms, infectious agents, and people. This influences pathogen rates of replication and proliferation, leading to a broader geographic distribution of pathogenic agents and an increase in species affected by disease outbreaks [ 7 , 8 ]. This makes disease outbreaks an important constraint to this industry, with a significant impact on the quality, safety and volume of the fish produced throughout the world [ 9 , 10 , 11 , 12 ], that can lead to market access exclusion and major economic loss or costs to the producer [ 8 , 13 , 14 ].…”