Risks associated with enterococci as probiotics

Wang, Xingmin; Yang, Yonghong; Huycke, Mark M.

doi:10.1016/j.foodres.2019.108788

Cited by 32 publications

(23 citation statements)

References 159 publications

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“…Because they harbor an underexploited, diverse microbiota [47], traditional, artisanal cheeses have been successfully screened for enterococcal strains with probiotic potential [205,235,[243][244][245]. Enterococcal probiotics have, so far, met with limited commercial success, and only under the form of dietary supplements [246]; however, foods such as fresh cheese would also serve as suitable carrier for probiotic microorganisms [247,248]. The major constraints upon commercial application of enterococci in probiotic preparations and foods for human consumption arise from safety concerns, insufficient information on their safety-related properties and health benefits, and unfavorable regulatory environment [8].…”

Section: Enterococci and Potential Health Benefits Of Dairy Productsmentioning

confidence: 99%

Current Trends of Enterococci in Dairy Products: A Comprehensive Review of Their Multiple Roles

Dapkevicius

Sgardioli

Câmara

et al. 2021

Foods

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As a genus that has evolved for resistance against adverse environmental factors and that readily exchanges genetic elements, enterococci are well adapted to the cheese environment and may reach high numbers in artisanal cheeses. Their metabolites impact cheese flavor, texture, and rheological properties, thus contributing to the development of its typical sensorial properties. Due to their antimicrobial activity, enterococci modulate the cheese microbiota, stimulate autolysis of other lactic acid bacteria (LAB), control pathogens and deterioration microorganisms, and may offer beneficial effects to the health of their hosts. They could in principle be employed as adjunct/protective/probiotic cultures; however, due to their propensity to acquire genetic determinants of virulence and antibiotic resistance, together with the opportunistic character of some of its members, this genus does not possess Qualified Presumption of Safety (QPS) status. It is, however, noteworthy that some putative virulence factors described in foodborne enterococci may simply reflect adaptation to the food environment and to the human host as commensal. Further research is needed to help distinguish friend from foe among enterococci, eventually enabling exploitation of the beneficial aspects of specific cheese-associated strains. This review aims at discussing both beneficial and deleterious roles played by enterococci in artisanal cheeses, while highlighting the need for further research on such a remarkably hardy genus.

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Section: Enterococci and Potential Health Benefits Of Dairy Productsmentioning

confidence: 99%

Current Trends of Enterococci in Dairy Products: A Comprehensive Review of Their Multiple Roles

Dapkevicius

Sgardioli

Câmara

et al. 2021

Foods

View full text Add to dashboard Cite

show abstract

“…Another important consideration is the risk associated with certain strains of probiotics such as the Enterococcus genus, which can acquire antibiotic resistance and become pathogenic. To date, no enterococcal probiotics have been approved for human use, leading the European Food Safety Authority to conclude that “ Enterococci do not meet the standard for Qualified Presumption of Safety” ( Wang et al, 2020 ). Given these data, along with studies showing their systemic effects ( Valdéz et al, 2005 ; Petricevic et al, 2008 ; Keely et al, 2012 ), probiotics are a promising potential treatment for GI-ARS and other radiation injuries.…”

Section: The Effects Of the Microbiome On The Radiation Responsementioning

confidence: 99%

Acute Radiation Syndrome and the Microbiome: Impact and Review

et al. 2021

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Study of the human microbiota has been a centuries-long endeavor, but since the inception of the National Institutes of Health (NIH) Human Microbiome Project in 2007, research has greatly expanded, including the space involving radiation injury. As acute radiation syndrome (ARS) is multisystemic, the microbiome niches across all areas of the body may be affected. This review highlights advances in radiation research examining the effect of irradiation on the microbiome and its potential use as a target for medical countermeasures or biodosimetry approaches, or as a medical countermeasure itself. The authors also address animal model considerations for designing studies, and the potential to use the microbiome as a biomarker to assess radiation exposure and predict outcome. Recent research has shown that the microbiome holds enormous potential for mitigation of radiation injury, in the context of both radiotherapy and radiological/nuclear public health emergencies. Gaps still exist, but the field is moving forward with much promise.

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“…Previously, animal studies reported that intake of a high‐unsaturated fat‐rich diet would increase Actinobacteria (Lactobacillus and Streptococcus) and Verrucomicrobia. Probiotics intake, such as cultured milk products and yogurt, is a source of ingestible microorganisms 22 . Diet containing high fat can increase Lipopolysaccharides (LPS) translocation 23 .…”

Section: Influence Of Diet On Gut Microbiotamentioning

confidence: 99%

“…Probiotics intake, such as cultured milk products and yogurt, is a source of ingestible microorganisms. 22 Diet containing high fat can increase Lipopolysaccharides (LPS) translocation. 23 Common food like fruits, vegetables and tea are all rich in polyphenols.…”

Section: Influen Ce Of D Ie T On G Ut Microb Iotamentioning

confidence: 99%

Role of gut microbiota‐derived metabolites on vascular calcification in CKD

Yin

Ghosh

et al. 2020

J Cellular Molecular Medi

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The interaction between gut microbiota and the host has gained widespread concern. Gut microbiota not only provides nutrients from the ingested food but also generates bioactive metabolites and signalling molecules to impact host physiology, especially in chronic kidney disease (CKD). The development of CKD, accompanied by changed diet and medication, alters the gut flora and causes the effect in distant organs, leading to clinical complications. Vascular calcification (VC) is an actively regulated process and a high prevalence of VC in CKD has also been linked to an imbalance in gut microbiota and altered metabolites. In this review, we focused on gut microbiota‐derived metabolites involved in VC in CKD and explained how these metabolites influence the calcification process. Correcting the imbalance of gut microbiota and regulating microbiota‐derived metabolites by dietary modification and probiotics are new targets for the improvement of the gut‐kidney axis, which indicate innovative treatment options of VC in CKD.

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Risks associated with enterococci as probiotics

Cited by 32 publications

References 159 publications

Current Trends of Enterococci in Dairy Products: A Comprehensive Review of Their Multiple Roles

Current Trends of Enterococci in Dairy Products: A Comprehensive Review of Their Multiple Roles

Acute Radiation Syndrome and the Microbiome: Impact and Review

Role of gut microbiota‐derived metabolites on vascular calcification in CKD

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