Risks and Complications of Vasectomy

Adams, Christopher E.; Wald, Moshe

doi:10.1016/j.ucl.2009.05.009

Cited by 77 publications

(37 citation statements)

References 35 publications

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“…The percentage of complications is comparable to other common office-based procedures, like vasectomy [79], and lower than that reported for procedures routinely performed in ASCs, such as colonoscopy [80]. To ensure that abortion remains safe, reproductive health policies should aim to reduce existing disparities in access to the service [81,82], rather than placing unnecessary restrictions on abortion providers and facilities.…”

Section: Accepted Manuscriptmentioning

confidence: 88%

Complications from first-trimester aspiration abortion: a systematic review of the literature

2015

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Section: Accepted Manuscriptmentioning

confidence: 88%

Complications from first-trimester aspiration abortion: a systematic review of the literature

2015

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“…Although not confirmed (4), the initial findings have continued to influence clinical decisions regarding vasectomy (7). Despite the uncertainties, studies on the basic mechanism of response to vasectomy have only been proposed (4) but not investigated (1). We now initiate a study with the premise that early immunological changes before sperm antibody detection can modify late events, and may unravel a mechanistic link to human systemic disease.…”

Section: Foxp3mentioning

confidence: 99%

Regulatory T cells control tolerogenic versus autoimmune response to sperm in vasectomy

Wheeler

Tardif

Rival

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

114

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Vasectomy is a well accepted global contraceptive approach frequently associated with epididymal granuloma and sperm autoantibody formation. To understand the long-term sequelae of vasectomy, we investigated the early immune response in vasectomized mice. Vasectomy leads to rapid epithelial cell apoptosis and necrosis, persistent inflammation, and sperm granuloma formation in the epididymis. Vasectomized B6AF1 mice did not mount autoimmune response but instead developed sperm antigen-specific tolerance, documented as resistance to immunization-induced experimental autoimmune orchitis (EAO) but not experimental autoimmune encephalomyelitis. Strikingly, tolerance switches over to pathologic autoimmune state following concomitant CD4+ regulatory T cell (Treg) depletion: unilaterally vasectomized mice produce dominant autoantibodies to an orchitogenic antigen (zonadhesin), and develop CD4 T-cell-and antibody-dependent bilateral autoimmune orchitis. Therefore, (i) Treg normally prevents spontaneous organ-specific autoimmunity induction by persistent endogenous danger signal, and (ii) autoantigenic stimulation with sterile autoinflammation can lead to tolerance. Finally, postvasectomy tolerance occurs in B6AF1, C57BL/6, and A/J strains. However, C57BL/6 mice resisted EAO after 60% Treg depletion, but developed EAO after 97% Treg reduction. Therefore, variance in intrinsic Treg functiona possible genetic trait-can influence the divergent tolerogenic versus autoimmune response to vasectomy.vasoligation | testis autoantigen | granulomatous inflammation | innate response

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“…Complications from vasectomy are rare and minor in nature. 16 Vasectomy acceptance and prevalence has been declining in India from 74.2% (proportion of all sterilizations) in 1970 to 4.2% in 1992 and 1% in 2016. Barriers in the organizational structure and poor access to services may contribute to the decrease in vasectomies.…”

Section: Duringmentioning

confidence: 99%

Complications of female sterilization procedure: review over a decade at district tertiary care hospital

Mule

Date

Gadekar

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Female sterilization is the most requested permanent contraceptive method worldwide and one of the most frequently performed elective, intra-abdominal surgical procedure in reproductive-age women. Even though considered as simple and safe procedure, complications do occur including death. Methods: The primary objective of the following study is to determine the demographic patterns of women presenting as sterilization complications and secondary is to evaluate possible etiological factors leading to complications and lay standard guidelines to reduce complication rate. Results: Over a decade, 103 cases of female sterilization related complications were documented, out of 14 cases (13.6%) were of laparoscopic tubal ligation and rest 89 were minilaparotomy (86.4%). In 3 cases tubal ligation was not performed as surgeon was not able to either open peritoneal cavity or find fallopian tubes due to adhesions (2.91%). In 70 cases (67.96%) sterilization were performed in primary health centre (PHC). Four patients (3.88%) required hospital stay of more than a month with longest stay being 43 days. Exploratory laparotomy with surgical intervention was done in 34 cases (33%). Two patients (1.94%) died due to tubectomy complications due to septicemia and encephalitis. Conclusions: Female sterilization is very popular and commonly performed permanent method of sterilization but complications can happen and many of them are preventable with proper screening and selection of cases with proper evaluation before surgery. There is a need to have proper training in sterilization and to stick to standards of sterilization procedure to minimize chances of complications.

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Risks and Complications of Vasectomy

Cited by 77 publications

References 35 publications

Complications from first-trimester aspiration abortion: a systematic review of the literature

Complications from first-trimester aspiration abortion: a systematic review of the literature

Regulatory T cells control tolerogenic versus autoimmune response to sperm in vasectomy

Complications of female sterilization procedure: review over a decade at district tertiary care hospital

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