Risk, treatment duration, and recurrence risk of postpartum affective disorder in women with no prior psychiatric history: A population-based cohort study

Rasmussen, Marie-Louise Hee; Strøm, Marin; Wohlfahrt, Jan; Videbech, Poul; Melbye, Mads

doi:10.1371/journal.pmed.1002392

Cited by 70 publications

(62 citation statements)

References 38 publications

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“…Data were linked from Danish national registers to follow 457 317 primiparous women without previous psychiatric diagnoses delivering between 1996 and 2013 3. These women were followed up until 31 December 2014.…”

Section: Methods Of the Studymentioning

confidence: 99%

Women with a history of postpartum affective disorder at increased risk of recurrence in future pregnancies

Gordon

Wilson

2018

Evid Based Mental Health

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Section: Methods Of the Studymentioning

confidence: 99%

Women with a history of postpartum affective disorder at increased risk of recurrence in future pregnancies

Gordon

Wilson

2018

Evid Based Mental Health

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“…Suicidal thoughts are extremely common, affecting about 20% of women with PPD symptoms [1][2][3][4][5]. PPD is one of the most common complications of childbirth and a major public health problem.…”

Section: Introductionmentioning

confidence: 99%

Effect of Gut Microbiotas Diversity During 32-39 Weeks of Gestation on Postpartum Depression

Zhang¹,

Gan²,

Yang³

et al. 2020

Preprint

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Background: Patients with major depression are accompanied by intestinal flora flocculation; however, the relationship between the composition of gut microbiota in pregnancy and postpartum depression (PPD) has not been established. In this study we determined the effect of the gut microbiota in pregnant women during 32-39 weeks of gestation on PPD.Methods: Participants (n = 74) were enrolled between 2016–2017 from the Guangzhou Women and Children’s Medical Centre (GWCMC). Stool samples were collected during 32-39 weeks of gestation, and the relative abundance of fecal microbiota was characterized by 16S rRNA sequencing. The parturients completed the mainland Chinese version of the Edinburgh Postnatal Depression Scale (EPDS) 42 days postpartum to detect PPD. The linear discriminant analysis (LDA) effect size (LEfSe) method was used to identify bacterial population differences between the PPD and control groups.Results: The top three bacteria phyla in the PPD and control groups were Firmicutes, Bacteroidetes, and Actinobacteria. Compared with healthy pregnant women, the alpha diversity index of the PPD group was lower. Beta diversity analysis was performed by PCoA showing that no significant differences in bacterial community structures between the two groups (R2 = 0.013, P = 0.549). The composition of gut microbiota during 32-39 weeks of gestation of the two groups was different. At the genera level, Acinetobacter, Plesiomonas, Enterococcus, Olsenella, Alloscardovia, and Anaerotruncus were increased in the PPD group, while Lactococcus, Adlercreutzia, Clostridium, Coprococcus, and unclassified-Clostridiales were decreased. At the species level, hypermegale, uli, casseliflavus, and hathewayi were increased in the PPD group, and celatum was increased in the control group.Conclusions: During 32-39 weeks of gestation, a reduction in diversity of gut microbiota and anti-inflammatory bacteria, and an increase in opportunistic pathogenic bacteria are more likely to cause PPD.

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“…The many changes experienced while becoming a mother, increase the risk of developing a mental illness [1][2][3][4]. One in five women will experience mental health issues during the perinatal period [4,5].…”

Section: Introductionmentioning

confidence: 99%

Perinatal Assessment of Risk of Mental Illness: Experience of First-time Mothers and Clinicians, Australian Private Hospitals

Sims

Fowler

Catling

et al. 2019

Preprint

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Background The many changes in becoming a mother increase the risk of developing a mental illness in the perinatal period. Comprehensive, psychosocial assessment for risk of mental illness is recommended as part of routine perinatal care for all women. In Australia, this assessment was less likely to be undertaken for women who gave birth in a private hospital compared to women who gave birth in a public hospital. Therefore this study aimed to explore the experience of perinatal assessment of risk of mental illness for first-time mothers who gave birth in a private hospital. Method The results are from an explanatory mixed-methods study on the risk of the development of a perinatal mental illness and its relationship with the delivery of, or lack thereof, a parenting support service. Interviews were conducted with first-time mothers, midwives, nurses, obstetricians and paediatricians at two Australian metropolitan private hospitals. Content analysis of the interview data provided exploration and interpret their experience of assessment of risk of mental illness. Results Interview data were gathered from 32 participants. Four themes on assessment of risk of mental illness for these women were described: part of routine perinatal care; comprehensive psychosocial assessment; coordination between care providers and lack of mental health resources. Conclusion For mothers who gave birth in a private hospital, comprehensive psychosocial assessment of risk of mental illness may not have been provided as part of the routine perinatal care and not coordinated between care providers. A lack of mental health resources cannot be regarded as a barrier to provision of these services.

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Risk, treatment duration, and recurrence risk of postpartum affective disorder in women with no prior psychiatric history: A population-based cohort study

Cited by 70 publications

References 38 publications

Women with a history of postpartum affective disorder at increased risk of recurrence in future pregnancies

Women with a history of postpartum affective disorder at increased risk of recurrence in future pregnancies

Effect of Gut Microbiotas Diversity During 32-39 Weeks of Gestation on Postpartum Depression

Perinatal Assessment of Risk of Mental Illness: Experience of First-time Mothers and Clinicians, Australian Private Hospitals

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