Risk Stratification of Patients with Acute Coronary Syndrome

Bauer, Dávid; Toušek, Petr

doi:10.3390/jcm10194574

Cited by 8 publications

(6 citation statements)

References 86 publications

(88 reference statements)

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“…[5][6][7][8] Since early coronary intervention in high-risk patients has consistently been shown to enhance clinical outcomes, risk stratification is crucial. 10,12 In our study, the mean age was 57.21±12.22 years. Santos ES, et al reported age as 59.9±10.6 years.…”

Section: Discussionmentioning

confidence: 61%

“…9 As association between TIMI risk score and GRACE score with Syntax score is still debatable due to variability of the findings. 10 Therefore, it is important to generate local data so that both these risk stratification scales can be used extensively to risk stratify patients as soon as they are admitted so that their management can be tailored accordingly. As "National Institute of Cardiovascular Disease (NICVD)" is the major cardiac center of the country and the patient flow is from different socioeconomic status from all over Pakistan and there is marked cultural diversity as well, hence the findings of our study were thought to be more representative of the target population in order to generalize our conclusions.…”

Section: Introductionmentioning

confidence: 99%

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Correlation of TIMI Risk Score and GRACE Risk Score with Lesion of Coronary Artery Disease in Patients with Non-ST Segment Elevation Acute Coronary Syndrome

Hassan,

Kubra,

Sabeen

et al. 2023

PJMHS

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Objective: To compare the correlation of “thrombolysis in myocardial infarction (TIMI)” and “Global Registry of Acute Coronary Events (GRACE)” risk score with lesion of coronary artery disease in patients with non-ST segment elevation acute coronary syndrome. Study Design: Cross-sectional study. Place and Duration: The Department of adult cardiology, “National Institute of Cardiovascular Diseases (NICVD)”, Karachi, Pakistan, from January 2021 to July 2021. Methodology: Demographics, weight, height, risk factors along with the required information needed for TIMI and GRACE score were obtained at the time of presentation in emergency department as per the scoring criteria. SYNTAX score was calculated after performing conventional angiography of the patients, using SYNTAX.com calculator. Results: In a total of 104 patients, the mean age was 57.21±12.22 years while 56 (53.8%) patients were male. Hypercholesterolemia was found in 33 (31.7%) patients. Mean score of TIMI was calculated as 4.680±2.064 while SYNTAX score was calculated as 26.45±12.94 and the correlation between TIMI risk score and SYNTAX score was noted as (r=0.109) and P value was found to be non-significant i.e. (P=0.270). Mean score of GRACE was noted as 135.38±90.88 while SYNTAX score was noted as 26.45±12.94 and the correlation between GRACE risk score and SYNTAX score was documented as (r=0.179) and P value was found to be non-significant i.e. (P=0.068). Practical Implications: Both TIMI and GRACE risk scoring systems showed weak correlations with SYNTAX scores. Conclusion: There is a weak correlation between TIMI risk score and SYNTAX score as well as GRACE risk score and SYNTAX score. Keywords: Acute coronary syndrome, coronary artery disease, GRACE score, myocardial infarction, thrombolysis.

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Section: Discussionmentioning

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Correlation of TIMI Risk Score and GRACE Risk Score with Lesion of Coronary Artery Disease in Patients with Non-ST Segment Elevation Acute Coronary Syndrome

Hassan,

Kubra,

Sabeen

et al. 2023

PJMHS

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“…In the last 40 years, major progress has been made in the management and treatment of ACS, and the prognoses of patients have significantly improved. However, continuous efforts are still being made to predict the outcome of patients with ACS [30]. LV dysfunction is a key prognostic factor in patients presenting ACS.…”

Section: Acute Coronary Syndromesmentioning

confidence: 99%

Echocardiographic Myocardial Work: A Novel Method to Assess Left Ventricular Function in Patients with Coronary Artery Disease and Diabetes Mellitus

Frișan,

Mornoș,

Lazăr

et al. 2024

Medicina

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Myocardial ischemia caused by coronary artery disease (CAD) and the presence of metabolic abnormalities and microvascular impairments detected in patients with diabetes mellitus (DM) are a common cause of left ventricular (LV) dysfunction. Transthoracic echocardiography is the most-used, non-invasive imaging method for the assessment of myocardial contractility. The accurate evaluation of LV function is crucial for identifying patients who are at high risk or may have worse outcomes. Myocardial work (MW) is emerging as an alternative tool for the evaluation of LV systolic function, providing additional information on cardiac performance when compared to conventional parameters such as left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS) because it incorporates deformation and load into its analysis. The potential of MW in various conditions is promising and it has gained increased attention. However, larger studies are necessary to further investigate its role and application before giving an answer to the question of whether it can have widespread implementation into clinical practice. The aim of this review is to summarize the actual knowledge of MW for the analysis of LV dysfunction caused by myocardial ischemia and hyperglycemia.

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“…However, the latest European Society of Cardiology (ESC) guidelines downgrade their prognostic importance. 4,5 TIMI risk score was clinically useful in the triage and management of fibrinolysis-eligible patients with STEMI decades ago and included a spectrum of admission variables, such as comorbidities, older age, hypotension, tachycardia, Killip classes II-IV, body weight below 70 kg, anterior STEMI, and more than a 4-hour treatment delay. 6 However, later studies demonstrated, in addition to timely use of primary PCI, other important predictors of prognosis such as prior resuscitation, TIMI III flow after primary PCI, in-hospital cardiogenic shock, bleeding, and acute kidney injury.…”

Section: Introductionmentioning

confidence: 99%

Factors of Hospital Mortality in Men and Women with ST-Elevation Myocardial Infarction – An Observational, Retrospective, Single Centre Study

Marinsek,

Šuran,

Sinkovic

2023

IJGM

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There are well-known gender differences in mortality of patients with ST-elevation myocardial infarction (STEMI). Our purpose was to assess factors of hospital mortality separately for men and women with STEMI, which are less well known. Patients and Methods: In 2018-2019, 485 men and 214 women with STEMI underwent treatment with primary percutaneous coronary intervention (PCI). We retrospectively compared baseline characteristics, treatments and hospital complications between men and women, as well as between nonsurviving and surviving men and women with STEMI. Results: Primary PCI was performed in 94% of men and 91.1% of women with STEMI, respectively. The in-hospital mortality was significantly higher in women than in men (14% vs 8%, p=0.019). Hospital mortality in both genders was associated significantly to older age, heart failure, prior resuscitation, acute kidney injury, to less likely performed and less successful primary PCI and additionally in men to hospital infection and in women to bleeding. In men and women ≥65 years, mortality was similar (13.3% vs 17.8%, p = 0.293). Conclusion: Factors of hospital mortality were similar in men and women with STEMI, except bleeding was more likely observed in nonsurviving women and infection in nonsurviving men.

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Risk Stratification of Patients with Acute Coronary Syndrome

Cited by 8 publications

References 86 publications

Correlation of TIMI Risk Score and GRACE Risk Score with Lesion of Coronary Artery Disease in Patients with Non-ST Segment Elevation Acute Coronary Syndrome

Correlation of TIMI Risk Score and GRACE Risk Score with Lesion of Coronary Artery Disease in Patients with Non-ST Segment Elevation Acute Coronary Syndrome

Echocardiographic Myocardial Work: A Novel Method to Assess Left Ventricular Function in Patients with Coronary Artery Disease and Diabetes Mellitus

Factors of Hospital Mortality in Men and Women with ST-Elevation Myocardial Infarction – An Observational, Retrospective, Single Centre Study

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