Risk-stratification models for Barrett’s esophagus: Will we get to the perfect classifier?

Chan, Man Wai; Pouw, Roos E.

doi:10.1016/j.gie.2022.02.028

Cited by 1 publication

(1 citation statement)

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“…This marker is not found in cells in the G0 phase. Proliferative activity correlates with the severity of Thus, the combination of inflammatory processes, oxidative stress, and increased proliferative activity can create a favorable environment for the progression of dysplastic and neoplastic changes in the mucosa, including Barrett's esophagus and adenocarcinoma [10,45,46].…”

Section: Intraepithelial Eosinophilsmentioning

confidence: 99%

Esophageal Mucosal Resistance in Reflux Esophagitis: What We Have Learned So Far and What Remains to Be Learned

et al. 2023

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Gastroesophageal reflux disease (GERD) has the highest prevalence among diseases of the digestive system and is characterized by a significant decrease in patients’ quality of life, comparable to arterial hypertension and coronary heart disease. One in every ten cases of reflux esophagitis leads to the formation of Barrett’s esophagus, which is associated with a high risk of esophagus adenocarcinoma. The key factors determining the progression of the disease are the frequency and duration of the reflux of the stomach’s contents. As a result, refluxate, which includes hydrochloric acid, pepsin, and, in the case of concomitant duodeno-gastric reflux, bile acids and lysolecithin, is thrown into the overlying sections of the digestive tract. At the same time, in addition to aggression factors, it is necessary to take into account the state of resistance in the esophageal mucosa to the effects of aggressive refluxate molecules. This review was prepared using systematized data on the protective properties of the esophageal mucosa and modern methods to assess the mucosal barrier in reflux esophagitis. Lesions of the epithelial barrier structure in the esophagus are recognized as the main pathogenetic factor in the development of reflux esophagitis and are a potentially significant therapeutic target in the treatment of GERD and Barrett’s esophagus. This article presents the characteristics of the esophageal mucosal barrier and the protective mechanisms of the esophagus’s mucous membrane in conditions of gastroesophageal reflux. Diagnostic approaches for assessing the course of reflux esophagitis are described for both histological criteria and the possibility of a comprehensive assessment of the state of mucins, tight-junction proteins, and the proliferative activity of the mucosa, including under the conditions of ongoing therapy.

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Section: Intraepithelial Eosinophilsmentioning

confidence: 99%