Risk Stratification Model for Severe COVID-19 Disease: A Retrospective Cohort Study

Reuveni, Miri Mizrahi; Kertes, Jennifer; David, Shirley Shapiro Ben; Shahar, Arnon; Shamir-Stein, Na’ama; Rosen, Keren; Liran, Ori; Bar-Yishay, Mattan; Adler, Limor

doi:10.3390/biomedicines11030767

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…The study population included all MHS members with a positive SARS-COV-2 PCR or reported antigen test (carried out by MHS or Ministry of Health (MOH)) from March 2020 (first case in Israel) until the beginning of July 2022 (end of study period). In MHS, most of the COVID-19 patients were followed up by either a centralized, bespoke, online service [4] or by their family physicians, on the basis of an organizational scoring system of corona-risk severity [19]. The study population was then divided into two groups: those who were treated in the Post-COVID-19 clinic and those who were not.…”

Section: Methodsmentioning

confidence: 99%

Use of a Virtual Multi-Disciplinary Clinic for the Treatment of Post-COVID-19 Patients

Rahamim-Cohen,

Kertes,

Feldblum

et al. 2024

Healthcare

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Post-COVID-19 has been recognized as possibly affecting millions of people worldwide. In order to optimize care and ensure equality, we established a multidisciplinary virtual Post-COVID-19 clinic (VPCC) within Maccabi Healthcare Services, the second largest HMO in Israel. This study aims to describe the structure, process and patient satisfaction with this clinic. The multidisciplinary team consisted of physicians, physiotherapists, social workers, occupational therapists and dieticians. Patient entry was to be at least four weeks after COVID-19 infection. A patient satisfaction survey was carried out 7–8 months after the clinic was closed. Demographic data were collected and compared to the general Maccabi COVID-19 population. The clinic treated 1614 patients, aged 16–91, over a period of 18 months. In total, 679 family physicians referred patients. In comparison to the general COVID-19 population, a higher percentage of the VPCC patients lived in the periphery of Israel, South (14.9% compared to 17.8%) and North (17.1% compared to 18.2%). In total, 249 patients answered the survey, and of them, 75% were highly satisfied with the medical care of the physician in the VPCC. A total of 54% of respondents would have preferred a face-to-face consultation, but 50% felt that communication was good in the virtual mode. In conclusion, the VPCC provided a dedicated service for patients, and the virtual format made it equally accessible to all parts of the country.

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Section: Methodsmentioning

confidence: 99%

Use of a Virtual Multi-Disciplinary Clinic for the Treatment of Post-COVID-19 Patients

Rahamim-Cohen,

Kertes,

Feldblum

et al. 2024

Healthcare

Self Cite

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“…One positive example would be the use of risk stratification models to identify patients that are at a higher risk of COVID-19 infection and severe illness [25]. These models have made possible the prioritization of patients requiring closer follow-up by their physicians and outreach services, as well as identifying those that are most likely to benefit from anti-viral treatment during the fifth wave of infection in Israel, dominated by the Omicron variant [26]. Precision public health by using more accurate measures of disease spread, susceptibility, and behavior to assess population health and develop targeted programs can also support broader COVID-19-related public health efforts [27].…”

Section: Aligning Precision Medicine With Evidence-based Medicine: Is...mentioning

confidence: 99%

The Buzz Surrounding Precision Medicine: The Imperative of Incorporating It into Evidence-Based Medical Practice

Muharremi,

Meçani,

Muka

2023

JPM

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Precision medicine (PM), through the integration of omics and environmental data, aims to provide a more precise prevention, diagnosis, and treatment of disease. Currently, PM is one of the emerging approaches in modern healthcare and public health, with wide implications for health care delivery, public health policy making formulation, and entrepreneurial endeavors. In spite of its growing popularity and the buzz surrounding it, PM is still in its nascent phase, facing considerable challenges that need to be addressed and resolved for it to attain the acclaim for which it strives. In this article, we discuss some of the current methodological pitfalls of PM, including the use of big data, and provide a perspective on how these challenges can be overcome by bringing PM closer to evidence-based medicine (EBM). Furthermore, to maximize the potential of PM, we present real-world illustrations of how EBM principles can be integrated into a PM approach.

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“…This autumn booster was offered to the Dutch population aged 12 years and older, and targeted especially clinically vulnerable individuals (medical risk group) and individuals aged 60 years and older (3). People with a medical risk and elderly people are at higher risk of developing severe disease after SARS-CoV-2 infection (4) and a high vaccination uptake in this group is thought to be essential to avoid excess morbidity and mortality (5,6,7).…”

Section: Introductionmentioning

confidence: 99%

Determinants of COVID-19 booster uptake in the Netherlands, autumn 2022: how well were those at risk for severe disease reached?

van Roekel,

Labuschagne,

Pijpers

et al. 2023

Preprint

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BackgroundA booster with bivalent COVID-19 vaccine was offered in the Netherlands in autumn, 2022. We aimed to investigate vaccine uptake during the autumn 2022 booster round among the population subgroups at risk for severe COVID-19 that were specifically targeted by this campaign: the medical risk group aged 18-59 years and individuals ≥60 years. We calculated booster uptake in both populations and analyzed determinants of booster uptake among those who had received at least one prior COVID-19 vaccination.MethodsHaving had an autumn 2022 booster dose was defined as having received a COVID-19 vaccination between 19 September 2022 and 7 March 2023. The study population included individuals who received at least one previous COVID-19 vaccination. National registries of sociodemographic determinants and COVID-19 vaccination were linked by a unique person identifier. Voting proportions for political parties were included at neighborhood level. Determinants of COVID-19 vaccine autumn booster uptake were ranked by importance by random forest analyses.ResultsBooster uptake was 68% among those aged ≥60 and 30% among those aged 18-59 years with a medical risk factor for severe disease. For both target groups the most important determinant for booster uptake was age (15% in 18-29 years to 72% in 80+ years). Voting proportions for progressive liberal political parties ranked second in the random forest analysis in both groups, with an increasing proportion of votes associated with higher uptake. In the 60+ group, household type ranked third, with highest vaccine uptake among married couples without children (72%) and the lowest uptake among unmarried couples with children (47%). In the medical risk group, migration status ranked third. Migrants with two parents born abroad had the lowest uptake (18%), whereas migrants with both parents born in the Netherlands had the highest uptake (35%).ConclusionAmong individuals who had received at least one prior COVID-19 vaccination, the autumn 2022 COVID-19 booster uptake was 68% in people ≥60 years and 30% in in the medical risk group aged 18-59 years. The most important determinant of booster uptake was age, followed by political preference and household type (60+ group) or migration status (medical risk group). Uptake varied considerably among subgroups in both target groups. Further research should be aimed at understanding the drivers and barriers of vaccine uptake among the subgroups with notably low uptake.

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Risk Stratification Model for Severe COVID-19 Disease: A Retrospective Cohort Study

Cited by 4 publications

References 17 publications

Use of a Virtual Multi-Disciplinary Clinic for the Treatment of Post-COVID-19 Patients

Use of a Virtual Multi-Disciplinary Clinic for the Treatment of Post-COVID-19 Patients

The Buzz Surrounding Precision Medicine: The Imperative of Incorporating It into Evidence-Based Medical Practice

Determinants of COVID-19 booster uptake in the Netherlands, autumn 2022: how well were those at risk for severe disease reached?

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