Risk stratification in early pregnancy for women at increased risk of gestational diabetes

A prospective cohort study of early‐pregnancy risk factors for gestational diabetes in polycystic ovarian syndrome

“…These findings are in agreement with observations from previous studies in PCOS women, highlighting the importance of IR in the pathogenesis of GDM . Importantly, previous studies demonstrated that FPG during early pregnancy is the strongest risk factor for GDM in the general population . In our study, women with higher blood pressures (systolic blood pressure and diastolic blood pressure) and a positive family history of hypertension were also noted to have a higher incidence of GDM.…”

“…[16][17][18] Importantly, previous studies demonstrated that FPG during early pregnancy is the strongest risk factor for GDM in the general population. 23,24 In our study, women with higher blood pressures (systolic blood pressure and diastolic blood pressure) and a positive family history of hypertension were also noted to have a higher incidence of GDM. Importantly, both hypertension and fasting glucose have been shown to predict development of type 2 diabetes, underlining similarities between the pathogenesis of GDM and type 2 diabetes.…”

The association between dysregulated adipocytokines in early pregnancy and development of gestational diabetes

“…Risk stratification of women at risk of GDM may facilitate streamlined antenatal care, targeted interventions to potentially reduce GDM and related risks, and prompt GDM screening and management . Clinical screening tools in women at high risk of GDM may be improved by addition of biomarkers reflecting early inflammation and insulin resistance .…”

“…Risk stratification of women at risk of GDM may facilitate streamlined antenatal care, targeted interventions to potentially reduce GDM and related risks, and prompt GDM screening and management. 4,22 Clinical screening tools in women at high risk of GDM may be improved by addition of biomarkers reflecting early inflammation and insulin resistance. 14,23 We used commercially available ELISA assays to measure novel serum adipocytokines and inflammatory biomarkers at 12 to 15 weeks in women identified at high risk for GDM based on a validated risk prediction tool.…”

“…The prevalence of GDM is rising, and the need for early identification of women at risk is well recognised. Early prediction enables risk stratification of women, facilitates opportunities for prevention of GDM, and may improve clinical outcomes . Screening methods using clinical risk factors have reasonable predictive ability but may be improved by combining inflammatory biomarkers that precede the onset of hyperglycaemia.…”