Purpose: To compare the surgical indicators, perioperative complications and postoperative psychological status of patients with coronary interventional therapy (CIT) by radical artery and femoral artery puncture approaches. Methods: 120 patients with CIT were divided into femoral artery group (FAG) and radial artery group (RAG) according to the operation ways. The interventional operation was performed by the same surgeon team and methods. Data of surgical indicators and perioperative complications were recorded and collected. The psychological questionare survey was made within 48 hours the after surgery by the hospital anxiety and depression scale (HAD), and the results were scored by the psychiatrist. Results: The age, sex, ethnicity, education level, disease type, and combined diseases of the two groups had homogeneity without statistical difference. There was no obvious difference in X-ray exposure time, contrast agent usage and operation time in two ways (P > 0.05). The success rate of one-time catheterization was higher in FAG than in RAG (P < 0.05). However, the incidence of vascular complications such as subcutaneous hematoma, puncture site bleeding in RAG were significantly lower than those in FAG (P < 0.05). Complications of vascular and puncture site bleeding, the operative limb braking time and hospitalization time were longer in FAG than those in the RAG (P < 0.05).The postoperative anxiety and depression question are data analysis showed patients in both groups had obvious higher anxiety and depression scores compare to Chinese norm. Even though there was no difference on anxiety scores of the patients in two groups, but the depression scores showed that patients in the FAG were more prone to psychological depression than patients in the RAG. Combined with the clinical nursing requirements, the postoperative nursing record charts of patients with CIT were established according to general patient data and physical discomfort with high incidence in the above survey