Risk Scoring Index for Development of Preeclampsia among Women: A Retrospective Cohort Study [39D]

Abstract

INTRODUCTION: Worldwide, there is an increasing thrust to develop better screening methods for preeclampsia. But in the Philippines, there is limited research regarding approach to screening for development of preeclampsia. This retrospective study aimed to identify significant clinical risk factors associated with preeclampsia and develop a risk scoring index. METHODS: A retrospective cohort study of women with live births at a tertiary hospital, St. Luke’s Medical Center from January 2015 to April 2016 was conducted. Several variables associated with Preeclampsia were considered. Outcome measure was development of preeclampsia. A risk scoring index was developed from the results of the logistic regression analysis. Computed scores were plotted in a receiver operating characteristic curve and cut-off values were determined. RESULTS: The overall prevalence of preeclampsia was 4.5%. Among the variables evaluated, presence of chronic hypertension (OR 4.179, 95% CI 7.572-563.181) and respiratory tract infection (OR 3.128, 95% CI 4.196-124.263) showed the strongest significant association with development of Preeclampsia. The odds of developing preeclampsia were also increased in patients who had gestational diabetes mellitus (OR 1.222, 95% CI 1.559-7.389), urinary tract infection (OR 2.455, 95% CI 5.723-23.678), and vaginal infection (OR 1.577, 95% CI 2.126-11.020). The formulated preeclampsia risk scoring index was 5.75, specificity of 91.8%, sensitivity of 74.5%, positive likelihood ratio of 9.2. CONCLUSION: Maternal age, and presence of chronic hypertension, gestational diabetes mellitus, and maternal infection significantly affect development of preeclampsia among women studied. Women are more likely to develop preeclampsia 9 times more with a risk score of greater than or equal to 5.75.

Analysis of the Reasons Which Are the Cornerstone of Pathogenesis of the Preeclampsia (Review)

“…По данным исследований, риск развития ПЭ был связан с наличием нарушений в МППК при проведении первого пренатального скрининга. Причем, к причинам, повышающим вероятность развития «ранней» ПЭ в сочетании с нарушениями кровотока в системе МППК относилась хроническая артериальная гипертензия, ожирение и сахарный диабет 1 типа [37].…”