Risk profile of methylmercury in seafood

Sevillano-Morales, Jesús Salvador; Cejudo-Gómez, Manuel; Ramírez-Ojeda, A. M.; Cámara-Martos, Fernando; Moreno-Rojas, Rafael

doi:10.1016/j.cofs.2016.01.003

Cited by 21 publications

(10 citation statements)

References 55 publications

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“…Human health risk assessment of Hg exposure was performed assuming all the Hg in YFT are present in methyl mercury (M-Hg) [ 9 ]. Some studies reported that the total Hg level in fish was identical to the M-Hg level [ 37 ]; however, Razavi et al [ 38 ] and Strandberg et al [ 39 ] reported that M-Hg in fish muscles is about 90% of the total Hg. Jinadasa et al [ 9 ] also assumed that ratio followed the same method for better comparisons in this study.…”

Section: Methodsmentioning

confidence: 99%

Comparative Study on the Distribution of Essential, Non-Essential Toxic, and Other Elements across Trophic Levels in Various Edible Aquatic Organisms in Sri Lanka and Dietary Human Risk Assessment

Wickrama-Arachchige

Guruge

Tani

et al. 2022

Toxics

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Thirty-six elements are categorized as essential but toxic in excess amount (EBTEs), non-essential toxic (NETs), and Other in 29 different edible aquatic species dwelling in offshore pelagic, and coastal and estuarine (CE) ecosystems were investigated in Sri Lanka. Elements were analyzed using an energy-dispersive X-ray fluorescence (EDXRF) spectrometer, and an NIC MA-3000 Mercury Analyzer. EBTEs showed a negative relationship, whereas NETs showed a positive relationship between the concentration (mg/kg wet weight) and trophic levels in both ecosystems. EBTEs showed trophic dilution, whereas NETs showed trophic magnification. Some elements in a few organisms exceeded the maximum allowable limit which is safe for human consumption. There was a positive relationship (R2 = 0.85) between the concentration of mercury and body weight of yellowfin tuna (YFT). For the widely consumed YFT, the calculated hazard index (HI) for the non-carcinogenic health and exposure daily intake of NETs for adults were 0.27 and 9.38 × 10−5 mg/kg bw/day, respectively. The estimated provisional tolerable weekly intake (PTWI) (μg/kg bw/w) was 0.47 for arsenic and 0.05 for antimony, cadmium, mercury, and lead. The HI and PTWI values were below the recommended limits; thus, consumption of YFT does not pose any health risk for Sri Lankan adults.

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Section: Methodsmentioning

confidence: 99%

Comparative Study on the Distribution of Essential, Non-Essential Toxic, and Other Elements across Trophic Levels in Various Edible Aquatic Organisms in Sri Lanka and Dietary Human Risk Assessment

Wickrama-Arachchige

Guruge

Tani

et al. 2022

Toxics

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“…53) The estimated intake of MeHg and Hg in some geographical areas are relatively low, and not exceeding the ADI. 54) Therefore, although the toxic level of MeHg exposure from the environment in our daily lives is decreasing, exposure can increase with sustained consumption of seafood with high levels of contamination of MeHg, and the MeHg concentration in the human brain can reach the levels studied here (100-300 nM). In fact, the mean MeHg concentrations in the cerebrum of residents living in non-polluted areas with mercury were as follows; 0.009 µg/g (41.7 nM) in 1972-1973, and 0.003 µg/g (13.9 nM) in 1987-1991.…”

Section: Discussionmentioning

confidence: 71%

Methylmercury Decreases AMPA Receptor Subunit GluA2 Levels in Cultured Rat Cortical Neurons

Ishida

Takeda

Takehara

et al. 2023

Biological & Pharmaceutical Bulletin

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Methylmercury (MeHg) is a well-known environmental pollutant that has harmful effects on the central nervous systems of humans and animals. The molecular mechanisms of MeHg-induced neurotoxicity at low concentrations are not fully understood. Here, we investigated the effects of low-concentration MeHg on the cell viability, Ca 2 homeostasis, and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit GluA2 levels, which determine Ca 2 permeability of AMPA receptors, in rat primary cortical neurons. Exposure of cortical neurons to 100 and 300 nM MeHg for 7 d resulted in a decrease in GluA2 levels, an increase in basal intracellular Ca 2 concentration, increased phosphorylation levels of extracellular signal-regulated kinase (ERK)1/2 and p38, and decreased cell viability. Moreover, glutamate stimulation exacerbated the decrease in cell viability and increased intracellular Ca 2 levels in MeHg-treated neurons compared to control neurons. MeHg-induced neuronal cell death was ameliorated by 1-naphthyl acetyl spermine, a specific antagonist of Ca 2 -permeable, GluA2-lacking AMPA receptors. Our findings raise the possibility that decreased neuronal GluA2 levels and the subsequent increase in intracellular Ca 2 concentration may contribute to MeHg-induced neurotoxicity.

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“…Algae can absorb large amounts of heavy metals, such as mercury, cadmium, lead, copper, and thallium [ 90 ]. Methylmercury, as an organic compound, can cause chronic toxic reactions after entering the human body, which may lead to great pain or organ failure [ 91 ]. Therefore, this issue has aroused great attention from countries all over the world.…”

Section: Chemical Factors Affecting Food Safety In Algaementioning

confidence: 99%

Current Status and Future Trends in Removal, Control, and Mitigation of Algae Food Safety Risks for Human Consumption

Zhuang

Chew

et al. 2022

Molecules

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With the rapid development of the economy and productivity, an increasing number of citizens are not only concerned about the nutritional value of algae as a potential new food resource but are also, in particular, paying more attention to the safety of its consumption. Many studies and reports pointed out that analyzing and solving seaweed food safety issues requires holistic and systematic consideration. The three main factors that have been found to affect the food safety of algal are physical, chemical, and microbiological hazards. At the same time, although food safety awareness among food producers and consumers has increased, foodborne diseases caused by algal food safety incidents occur frequently. It threatens the health and lives of consumers and may cause irreversible harm if treatment is not done promptly. A series of studies have also proved the idea that microbial contamination of algae is the main cause of this problem. Therefore, the rapid and efficient detection of toxic and pathogenic microbial contamination in algal products is an urgent issue that needs to be addressed. At the same time, two other factors, such as physical and chemical hazards, cannot be ignored. Nowadays, the detection techniques are mainly focused on three major hazards in traditional methods. However, especially for food microorganisms, the use of traditional microbiological control techniques is time-consuming and has limitations in terms of accuracy. In recent years, these two evaluations of microbial foodborne pathogens monitoring in the farm-to-table chain have shown more importance, especially during the COVID-19 pandemic. Meanwhile, there are also many new developments in the monitoring of heavy metals, algal toxins, and other pollutants. In the future, algal food safety risk assessment will not only focus on convenient, rapid, low-cost and high-accuracy detection but also be connected with some novel technologies, such as the Internet of Things (artificial intelligence, machine learning), biosensor, and molecular biology, to reach the purpose of simultaneous detection.

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Risk profile of methylmercury in seafood

Cited by 21 publications

References 55 publications

Comparative Study on the Distribution of Essential, Non-Essential Toxic, and Other Elements across Trophic Levels in Various Edible Aquatic Organisms in Sri Lanka and Dietary Human Risk Assessment

Comparative Study on the Distribution of Essential, Non-Essential Toxic, and Other Elements across Trophic Levels in Various Edible Aquatic Organisms in Sri Lanka and Dietary Human Risk Assessment

Methylmercury Decreases AMPA Receptor Subunit GluA2 Levels in Cultured Rat Cortical Neurons

Current Status and Future Trends in Removal, Control, and Mitigation of Algae Food Safety Risks for Human Consumption

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