Risk Prediction and New Prophylaxis Strategies for Thromboembolism in Cancer

Ferroni, Patrizia; Guadagni, Fiorella; Roselli, Mario

doi:10.3390/cancers13071556

Cited by 1 publication

(1 citation statement)

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“…In cancer patients with active or uncontrolled cancer, the risk of recurrence of VTE may be high depending on the location of the primary tumor. Neoplasms such as pancreatic cancer, neoformations of the brain, lungs, and ovaries, various myeloproliferative or myelodysplastic disorders, and all advanced stage IV cancers associated with concomitant situations of disability are at increased risk of thromboembolic complications [67]. The role played by advancing age in VTE recurrence is not yet fully understood, but thromboembolic events are unrelated to the patient's age, since older age and younger age are the groups most associated with the risk of recurrence mainly among women [68], while in another study [69] there was no gender difference considering the patient's age during relapse.…”

Section: Vte Outcomes and Gender Differencesmentioning

confidence: 99%

Gender Medicine: A New Possible Frontiers of Venous Thromboembolism

2023

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From the data in our possession derived from the literature, it has been shown that men have a high risk and appear to have a specific higher risk of suffering from thromboembolism than women, regardless of age group. Furthermore, at present, this difference between the two sexes has not yet been justified by scientific evidence. Taking this evidence into account, this review was designed to find information in the literature that could be potentially useful and that is crucial to knowledge about the differences between men and women in the genesis of thromboembolic disease. The role of the constitutional and physical factors underlying the difference between the two sexes, the different habitual lifestyles, the role of sex hormones, and what happens in situations such as venous thromboembolism in the course of a neoplastic disease or in the case of pregnancy. We have also focused our efforts on correlating the gender differences between men and women in thromboembolic disease with the dysregulation of the metabolism and the activation of the inflammatory response that often underlies this pathology.

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Section: Vte Outcomes and Gender Differencesmentioning

confidence: 99%