Abstract:PurposeTo elucidate risk potentiality of frontline radiotherapy associated cataracts in primary ocular adnexal mucosa-associated lymphoid tissue lymphoma (OAML).MethodsData from eight consecutive patients of 41 total OAML patients who had undergone cataract surgery after frontline radiotherapy were analyzed.ResultsThe median patient age was 46 years (range, 36 to 69 years). The median total radiation dose was 3,780 cGy (range, 3,060 to 4,500 cGy), and the mean duration from radiation irradiation to cataract su… Show more
“…25 Posterior subcapsular cataracts are the cataract type that is most commonly seen following radiotherapy in the orbit. 26 Lens shielding has been found to reduce the incidence of radiation-induced cataracts in previous studies, 8,12,27,28 which was confirmed in our series. Cataracts were formed in 46% of patients who did not (Tables 5 and 6).…”
“…25 Posterior subcapsular cataracts are the cataract type that is most commonly seen following radiotherapy in the orbit. 26 Lens shielding has been found to reduce the incidence of radiation-induced cataracts in previous studies, 8,12,27,28 which was confirmed in our series. Cataracts were formed in 46% of patients who did not (Tables 5 and 6).…”
“…The pathogenesis of radiationrelated cataracts is debated and a threshold radiation dose for cataract development has not been established, but instead there seems to be a linear model of risk [31e33]. However, for patients developing radiation-related cataracts the outcome from surgery has been shown to be excellent [34]. The use of a lens-sparing technique prevented cataract formation, but was associated with a higher rate of acute erythema and conjunctivitis.…”
“…Twenty peer-reviewed articles were reviewed from 1997 to 2013 [4,8,12,14,15,16,22,23,24,25,26,27,28,29,30,31,32,33,34,35]. All patients treated with radiation therapy only were recorded.…”
Section: Resultsmentioning
confidence: 99%
“…The International Lymphoma Study Group classified 3 subtypes of MZL. This includes extranodal marginal zone B-cell lymphoma (EMZL), splenic marginal zone B-cell lymphoma, and nodal marginal zone B-cell lymphoma [1,2,7,8]. EMZL is the most frequent, low-grade, indolent, small B-cell lymphoma with a prolonged course of the ocular adnexa [9,10].…”
Aim: The aim of this study was to report outcomes following radiation therapy in patients with biopsy-proven extranodal marginal zone lymphoma of the ocular adnexa and uvea. Methods: Records from a single institution were retrospectively reviewed from January 1997 to December 2015. The mean follow-up duration was 38 months (range 0-194). Radiation therapy was administered to 77 eyes (60 patients); 57 of the 77 eyes (74%) were treated with radiation only (range 20-36 Gy, median 15 fractions). Radiation cataract, radiation retinopathy, and optic neuropathy assessments were performed on all eyes treated with radiation. Results: 100% of the 47 patients treated with radiation therapy only had local control with an average dose of 26.5 Gy (median 25.2 [range 20-36] Gy; 150-200 cGy per fraction). Four patients lost 2 lines or more of vision after radiation. The most common complication of radiation therapy was cataract formation/progression in 19 eyes (25%). Radiation retinopathy was observed only in 1 patient (1%). Conclusion: Our results confirm that radiation therapy (median 25 Gy) for extranodal marginal zone lymphoma of the ocular adnexa is associated with high local control and low risk of visually significant complications.
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