Risk, Outcomes, and Costs of Radiation-Induced Oral Mucositis Among Patients With Head-and-Neck Malignancies

Adipose mesenchymal stromal cells minimize and repair radiation-induced oral mucositis

“…RIOM side effects and sequels include: oral pain in 69% of patients, dysphagia in 56% of patients, opioid use in 53% of patients, weight loss of 3 to 7 kg, feeding tube insertion and hospitalization (ICU admission) in 15% of patients, and modification or interruption of treatment in 11-16% of patients [1,122,126].…”

“…At the USA, RIOM may add up to $ 1,700.00 -6,000.00 USD per patient depending of the inflammatory grade of the injury [122]. RIOM treatment added an economic cost that was estimated to increase up to $ 17,000.00 USD per patient treated for…”

Sepsis in head and neck cancer patients treated with chemotherapy and radiation: Literature review and consensus

“…Abbreviations: PaCO 2 = arterial carbon dioxide tension; MODS: Multi-organ Dysfunction Syndrome; Other abbreviations see the text. [28,29], generated by stressed host cells, or exogenous pathogen-associated molecular patterns (PAMPs) [30][31][32] are recognized as being capable of activating the pattern recognition receptors (PRRs) [33] of the immune cells and as promoting the synthesis of inflammation mediators. Thus, any kind of tissue damage (pathogens [34,35], CRT [8,9] etc.)…”

Individualized pharmacological treatment of oral mucositis pain in patients with head and neck cancer receiving radiotherapy

“…Fibrin coated ulcers [8] and increased risk of infection [7] are to be expected. A peak of OM severity is seen in the fifth week of RT [10]. The healing process starts two to three weeks after completed RT [8], but OM may remain severe five to seven weeks after the RT period [6].…”