Footwear workers are exposed to psychosocial factors at work, which may contribute to the development of Work-Related Musculoskeletal Disorders (WRMDs). Therefore, the purpose of this article is to assess the influence of psychosocial factors on the appearance of musculoskeletal symptoms in the lower limbs in workers in the footwear industry. Through a cross-sectional study of 267 workers, psychosocial factors were related to the occurrence of WRMD in the knee and foot using an ordinal logistic regression model, with significance level of 5%. The OR was used to estimate the increased chances of psychosocial and quantified factors through the Job Content Questionnaire (JCQ) and the WRMDs by an adaptation of the Nordic Questionnaire. For the factors associated with knee pain, the odds ratio was 18.6% (OR = 1.186, CI95% 1.012-1.382) for perceived physical effort, 17.5% (OR = 1.175, CI95% 1.011-1.367) for age and 3.6% (OR = 1.036, CI95%, 1.005-1.067) for low social support. (OR = 1.184, CI95% 1.042-1.345) for perceived physical effort, 13.9% (OR = 1.139, CI95% 1.010-1.284) for low social support and 8.5% (OR = 1.085, CI95% 1.026-1.147) for BMI, while a reduction in reward perception increases the chance of foot symptoms by 9.8% (OR = 0.902, CI95% 0.847-0.960). It is concluded that the factors of perception of physical effort and social support are common and contribute with symptoms for both regions of the lower limbs.