Risk of Venous Thrombosis With Use of Current Low-Dose Oral Contraceptives Is Not Explained by Diagnostic Suspicion and Referral Bias

Bloemenkamp, Kitty W. M.; Rosendaal, Frits R.; Büller, Harry R.; Helmerhorst, Frans M.; Colly, L. P.; Vandenbroucke, Jan P.

doi:10.1001/archinte.159.1.65

Cited by 123 publications

(85 citation statements)

References 32 publications

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“…7,8,10,31 Although the effects of third-generation OCs on the plasma levels of total and free protein S is relatively small, it should be emphasized that these concern mean changes and that in some individuals the changes are larger than the mean. Thus, it is possible that in a woman with a low protein S at baseline, a change in protein S larger than the mean may further disturb the hemostatic balance and increase the thrombotic risk.…”

Section: Discussionmentioning

confidence: 99%

Effect of second- and third-generation oral contraceptives on the protein C system in the absence or presence of the factor VLeiden mutation: a randomized trial

Kemmeren

Algra

Meijers

et al. 2004

Blood

136

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Section: Discussionmentioning

confidence: 99%

Effect of second- and third-generation oral contraceptives on the protein C system in the absence or presence of the factor VLeiden mutation: a randomized trial

Kemmeren

Algra

Meijers

et al. 2004

Blood

136

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“…This would lead to an overestimation of the risk of venous thrombosis after injury. One study, 20 also from the Netherlands, could not find a higher risk of being referred for venous thrombosis among women using oral contraceptives. However, we do not know whether this is also true for minor injuries.…”

Section: Commentmentioning

confidence: 97%

Minor Injuries as a Risk Factor for Venous Thrombosis

Stralen

Rosendaal²,

Doggen³

2008

Arch Intern Med

104

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“…33 Many reports have demonstrated that oral contraceptives, including the currently used low-dose oral contraceptives, increase the risk of thrombosis about 4-fold. [34][35][36] Most oral contraceptives contain an estrogen and a progestogen. The estrogen dose has over the years been reduced from 100 µg or more of ethinylestradiol to current formulations with 30 µg or less of ethinylestradiol.…”

Section: Oral Contraceptivesmentioning

confidence: 99%

Hypercoagulability: Too Many Tests, Too Much Conflicting Data

Bauer¹,

Rosendaal²,

Heit³

2002

Hematology

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It is now possible to identify hereditary and acquired risk factors in a substantial percentage of patients presenting with a venous thrombotic event. The clinician is faced with an ever-growing number of laboratory tests that can be ordered in such patients, and there is considerable uncertainty as to how this information should be utilized in patient management. Some have argued that widespread testing of thrombosis patients for prothrombotic abnormalities such as the factor V Leiden and prothrombin G20210A mutations has been prematurely adopted into clinical practice as there are few data that their identification leads to improved clinical outcomes.Dr. Rosendaal provides an overview of the epidemiology of venous thrombosis with an emphasis on hereditary and acquired risk factors. The presentation will include information obtained from properly designed case-control studies as well as family studies.While some have suggested treatment strategies for managing patients with hereditary thrombophilia with prior thrombotic events or for managing patients undergoing procedures associated with increased thrombotic risk, clinical decision making is complicated by the need to assess the risk of recurrence and the likely benefit of prolonged anticoagulation versus the associated bleeding risk. Drs. Bauer, Heit, and Rosendaal discuss their approaches to patient management. Case presentations are used to illustrate the impact of laboratory test results on decisions.

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Risk of Venous Thrombosis With Use of Current Low-Dose Oral Contraceptives Is Not Explained by Diagnostic Suspicion and Referral Bias

Cited by 123 publications

References 32 publications

Effect of second- and third-generation oral contraceptives on the protein C system in the absence or presence of the factor VLeiden mutation: a randomized trial

Effect of second- and third-generation oral contraceptives on the protein C system in the absence or presence of the factor VLeiden mutation: a randomized trial

Minor Injuries as a Risk Factor for Venous Thrombosis

Hypercoagulability: Too Many Tests, Too Much Conflicting Data

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