Risk of vascular disease and cognitive function in very old adults

Flint, Alastair J.; Bingham, Kathleen

doi:10.1017/s104161021800217x

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…Consistent with prior research (Ayyagari & Frisvold, 2016;Flint & Bingham, 2019;Kato et al, 2013;Li & Hsu, 2015;Park et al, 2019), demographic factors (age, gender, education, and income) and health status (self-rated health and vascular diseases) were associated with cognitive function trajectories. Race was also a significant predictor of cognitive functioning.…”

Section: Discussionsupporting

confidence: 83%

Trajectories of Multiple Behavioral Risk Factors and Their Associations With Cognitive Function Trajectories Among Older African Americans and White Americans

Chen

Liang

et al. 2021

J Aging Health

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Objectives: This study examined the joint trajectories of behavioral risk factors (smoking, alcohol drinking, and body mass index) and their associations with cognitive function trajectories among older African Americans and white Americans. Methods: Data from the Health and Retirement Study (1998–2014) were used. Group-based mixture modeling and multinomial logistic regression analysis were performed. Results: Three joint trajectories of behavioral risk factors (overweight, smoking and drinking, and drinking and overweight) and three cognitive function trajectories (low, moderate, and high) were identified. A significantly higher percentage of African Americans were in the “overweight,” “smoking and drinking,” and “low” cognitive functioning groups as measured by the total cognition composite score compared to white Americans. After accounting for covariates, the “drinking and overweight” group was associated with the “moderate” or “high” cognitive functioning group. Discussion: Future interventions targeting the combinations of behavioral risk factors are needed to promote healthy aging among high-risk populations.

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Section: Discussionsupporting

confidence: 83%

Trajectories of Multiple Behavioral Risk Factors and Their Associations With Cognitive Function Trajectories Among Older African Americans and White Americans

Chen

Liang

et al. 2021

J Aging Health

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“…Furthermore, the relationship between heart disease and cognitive functioning differed in the two populations, i.e., heart disease was associated with worse cognitive functioning in the US and better cognitive functioning in Japan. As eloquently discussed in the Commentary by Flint and Bingham, longevity is only 25% heritable, and is largely subject to environmental and behavioral influences including exercise, diet, and positive psychological traits (Flint and Bingham, 2019). Also, the paradoxical relationship between cognition and blood pressure in centenarians has important clinical implications for this subpopulation, as we strive to personalize medical care for each individual.…”

mentioning

confidence: 99%

Aging successfully and healthfully

Lee

2019

Int. Psychogeriatr.

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Premorbid factors of early post-stroke cognitive impairment

Grishina

Tynterova

Skalin

2022

V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY

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The aim of this study is to identify and substantiate early cognitive dysfunction in patients with brain damage in the acute period of ischemic stroke.Materials and research methods. The study included 140 elderly patients. The main group included 70 patients of Vascular Surgery Center with a diagnosis of ischemic stroke in the carotid pool, the control group consisted of 70 outpatients. Cognitive function and psycho-emotional background were assessed using the Montreal Cognitive Function Scale, tests for kinetic, constructive and ideation praxis, the Stroop test, the Boston Naming Test, the apathy rating scale, the Hospital Anxiety and Depression Scale, and the MFI-20 asthenia scale. Assessment of neuroimaging parameters was carried out usingcomputed tomography. Assessment of long-latency acoustic endogenous evoked potential P300 using the «oddball active» paradigm technique was used for neurophysiological examination.Research results. Ischemic stroke was more often detected in the parietal, frontal lobes and basal ganglia. Moderate cognitive impairment was detected in 57.5% of patients with stroke and 27.5% of the control group. Dementia was diagnosed in 30% of patients in the main group and 5% of the control group. In patients with IS indicators characterizing the executive function, praxis, speech, attention, memory, depression, and apathy were statistically significantly lower comparing with the control group. The analysis of neurophysiological data revealed a statistically significant prolongation of the latency of the P300 wave in all leads and a decrease in the amplitude of the P300 peak in leads Cz and C3 in patients of the main group. Conclusion. Within the framework of this study, significant factors in the development of early post-stroke cognitive impairment were established. Dysfunction in attention, executive function, episodic memory, and speech is the result of a combination of causes directly related to cerebrovascular disease and pre-stroke factors. The evoked potential method reflects the degree of cognitive decline and can be used as a method for assessing the effectiveness of cognitive rehabilitation in stroke patients.

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Risk of vascular disease and cognitive function in very old adults

Cited by 4 publications

References 18 publications

Trajectories of Multiple Behavioral Risk Factors and Their Associations With Cognitive Function Trajectories Among Older African Americans and White Americans

Trajectories of Multiple Behavioral Risk Factors and Their Associations With Cognitive Function Trajectories Among Older African Americans and White Americans

Aging successfully and healthfully

Premorbid factors of early post-stroke cognitive impairment

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