Risk of transfusion‐transmitted chikungunya infection and efficacy of blood safety implementation measures: experience from the 2009 epidemic in Songkhla Province, Thailand

Appassakij, Hatsadee; Promwong, Charuporn; Rujirojindakul, Pairaya; Khuntikij, Paiwon; Silpapojakul, Khachornsakdi

doi:10.1111/trf.13675

Cited by 10 publications

(11 citation statements)

References 19 publications

(104 reference statements)

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“…(6) Our donor questionnaire has an estimated 70% effectiveness for detecting symptomatic DENV and ZIKV infections. While we have not formally assessed this, we believe 70% represents a conservative estimate and is supported by the mean 83Á7% risk reduction for a CHIKV-specific questionnaire estimated by Appassakij et al (2016) [27]. (7) CHIKV is transfusion-transmitted.…”

Section: Application Of Modelmentioning

confidence: 65%

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Emerging infectious disease outbreaks: estimating disease risk in Australian blood donors travelling overseas

et al. 2017

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Background and Objectives International travel assists spread of infectious pathogens. Australians regularly travel to South‐eastern Asia and the isles of the South Pacific, where they may become infected with infectious agents, such as dengue (DENV), chikungunya (CHIKV) and Zika (ZIKV) viruses that pose a potential risk to transfusion safety. In Australia, donors are temporarily restricted from donating for fresh component manufacture following travel to many countries, including those in this study. We aimed to estimate the unmitigated transfusion‐transmission (TT) risk from donors travelling internationally to areas affected by emerging infectious diseases. Materials and Methods We used the European Up‐Front Risk Assessment Tool, with travel and notification data, to estimate the TT risk from donors travelling to areas affected by disease outbreaks: Fiji (DENV), Bali (DENV), Phuket (DENV), Indonesia (CHIKV) and French Polynesia (ZIKV). Results We predict minimal risk from travel, with the annual unmitigated risk of an infected component being released varying from 1 in 1·43 million to <1 in one billion and the risk of severe consequences ranging from 1 in 130 million to <1 in one billion. Conclusion The predicted unmitigated likelihood of infection in blood components manufactured from donors travelling to the above‐mentioned areas was very low, with the possibility of severe consequences in a transfusion recipient even smaller. Given the increasing demand for plasma products in Australia, the current strategy of restricting donors returning from select infectious disease outbreak areas to source plasma collection provides a simple and effective risk management approach.

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Section: Application Of Modelmentioning

confidence: 65%

“…While we have not formally assessed this, we believe 70% represents a conservative estimate and is supported by the mean 83·7% risk reduction for a CHIKV‐specific questionnaire estimated by Appassakij et al . (2016) . CHIKV is transfusion‐transmitted.…”

Section: Methodsmentioning

confidence: 99%

Emerging infectious disease outbreaks: estimating disease risk in Australian blood donors travelling overseas

et al. 2017

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“…Research and laboratory developed NAT assays demonstrated a high frequency of CHIKV RNA‐positive blood donors: 0·54% in Puerto Rico in 2014–2015 , 1·9% from September to November in Puerto Rico in 2014 (2·1% at the peak of the outbreak) and 0·4% in the French Caribbean (1–2% during the peak of the outbreak) in 2014–2015 . Mathematical models have been developed to estimate the risk of emerging infectious disease transmission through transfusion ; in Thailand in 2009, the mean risk and the maximum estimated risk for viremic blood donations in the absence of mitigation strategy were 0·9 and 4·8%, respectively .…”

Section: Discussionmentioning

confidence: 99%

Amustaline (S‐303) treatment inactivates high levels of Chikungunya virus in red‐blood‐cell components

et al. 2018

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“…In Bangladesh two outbreaks were reported in 2008 and in 2011 [3, 4]. In previous years, outbreaks had occurred in India [10, 11], Pakistan [12, 13], Thailand [14] and Brazil [15, 16].…”

Section: Discussionmentioning

confidence: 99%

Chikungunya: an emerging viral infection with varied clinical presentations in Bangladesh: Reports of seven cases

Rahim¹,

Uddin²

2017

BMC Res Notes

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BackgroundChikungunya is an emerging and rapidly spreading viral infection in many parts of the world including Bangladesh. It shares many epidemiological and clinical characteristics with dengue. So, a sound knowledge is required for its detection and differentiation from dengue, specially in endemic regions.Case presentationWe present seven confirmed cases of chikungunya having different clinical presentations occurring among middle aged males and females from different socio-economic background in Dhaka city, the capital of Bangladesh. All patients had fever and aches and pains. Less common features were rash, diarrhea, vomiting and altered liver biochemistry. Dengue was excluded in six patients. Paracetamol remained the mainstay of treatment during febrile periods, but over 50% of the patients had prolonged joint symptoms requiring non-steroidal anti-inflammatory drugs.ConclusionsIn spite of being a self-limiting disease, chikungunya may have different presentations and a protracted clinical course. During the febrile episode, exclusion of dengue is equally important. Physicians should be aware of the condition and public health initiatives are necessary to break the disease transmission.

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Risk of transfusion‐transmitted chikungunya infection and efficacy of blood safety implementation measures: experience from the 2009 epidemic in Songkhla Province, Thailand

Abstract: This study suggests that prompt blood screening measures can reduce the risk of transfusion-transmitted CHIKF and maintain a safe blood supply during an outbreak.

Cited by 10 publications

References 19 publications

Emerging infectious disease outbreaks: estimating disease risk in Australian blood donors travelling overseas

Emerging infectious disease outbreaks: estimating disease risk in Australian blood donors travelling overseas

Amustaline (S‐303) treatment inactivates high levels of Chikungunya virus in red‐blood‐cell components

Chikungunya: an emerging viral infection with varied clinical presentations in Bangladesh: Reports of seven cases

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