Risk of Thromboembolus after Application of Different Tissue Glues during Microvascular Anastomosis

Ritschl, Lucas M.; Fichter, Andreas M.; Düring, Monika von; Mitchell, David A.; Wolff, Klaus‐Dietrich; Mücke, Thomas

doi:10.1097/prs.0000000000001808

Cited by 12 publications

(28 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 467 patients who underwent craniotomy for resection of meningiomas, a significant association was found between the volume of FloSeal used intraoperatively and the incidence of PE ( P = 0.02) . Furthermore, in a recent animal study by Ritschl et al ., thromboembolic material was demonstrated significantly more frequently in the distally inserted micropore filter in all tissue glue groups, independent of tissue glue type …”

Section: Discussionmentioning

confidence: 86%

“…There have been previous studies that identified the association between the use of FloSeal and incidence of embolisms . In particular, there has been a report of a fatal PE by locally applied haemostatic matrix after surgical removal of spinal schwannoma .…”

Section: Discussionmentioning

confidence: 99%

“…The collagen or gelatin granules from these agents restrict blood flow and provide a physical matrix to support clot formation, while delivering thrombin to exposed microvessels to activate clotting. Recent studies suggest that this may potentially activate systemic coagulation resulting in thromboembolic events . Safaee et al analysed 467 patients who underwent craniotomies for meningioma and found a significant association between the volume of FloSeal (Baxter Healthcare, Deerfield, IL, USA) used intraoperatively and the incidence of postoperative PE.…”

Section: Introductionmentioning

confidence: 99%

“…Safaee et al analysed 467 patients who underwent craniotomies for meningioma and found a significant association between the volume of FloSeal (Baxter Healthcare, Deerfield, IL, USA) used intraoperatively and the incidence of postoperative PE. In an experimental animal study, Ritschl et al investigated the thromboembolic risk of three different tissue glues (fibrin, FloSeal or TachoSil (Baxter Healthcare)) in vascular anastomosis and reported a significant increase in thromboembolism in the experimental groups …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Use of thrombin‐based haemostatic matrix in head and neck reconstructions: a potential risk factor for pulmonary embolism

Yue

Zinn

Roberts

et al. 2016

ANZ Journal of Surgery

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Use of thrombin‐based haemostatic matrix in head and neck reconstructions: a potential risk factor for pulmonary embolism

Yue

Zinn

Roberts

et al. 2016

ANZ Journal of Surgery

View full text Add to dashboard Cite

show abstract

“…This accidents well leading to thrombosis and tissue ischemia [2]. Many researches were done to improved the vascular anastomosis techniques steps and outcome results as using clips, coupling devices, adhesive and gel substances, leaser, and stents [3][4][5][6][7]. The ideal method for vascular anastomosis must be easy (has short learning cure), short time consuming, maintain normal blood fl ow, and not leading to thrombosis and ischemia immediately or later on.…”

Section: Introductionmentioning

confidence: 99%

Closed removable thread vascular anastomosis stent (Lasheen Vascular Stent)

Lasheen¹

2019

J Surg Surgical Res

View full text Add to dashboard Cite

Background: Vascular anastomosis is a most common and important part of many reconstructive transplant procedures. Venous anastomosis can be done by using coupling devices. In arterial anastomosis still the suture method is the main method, which is time consuming, need much experience, and associated by many complications specially with small arteries (microanastomosis). This study offers new type of stent (Lasheen vascular stent) for vascular anastomosis.Methods: This experimental study included 7 Egyptian native dogs. Under general anesthesia, the femoral artery was exposed and cut, then re-anastomosis by using thread vascular stent of suitable caliber. Where one end of stent passed from the lumen of distal end of femoral artery and passed through the tissue to appear on skin. Other end of stent passed from the lumen of proximal end of femoral artery through the tissue to appear on skin. Four sutures were taken to approximate two femoral ends on stent. Then, the wound closed in its layers with stent in its position and both stent ends were fi xed on skin. After, two weeks the stent was removed by traction on both stent ends to change the stent to thread and come out of body. Results:The mean time to put the stent in right position was 10 minutes. The prophylactic dose of antithrombotic drug given for three days and antiplatelet aggregation drug for 15 days. All anastomosis were clearly patent by clinical observation and duplex scanning if needed during period of follow up (3 months). No leakage during procedure or hematoma after stent removal were observed. Conclusion:Lasheen vascular stent for vascular anastomosis is rapid , less time consumed, has short learning curve and good results, and with no special complications.Citation: Lasheen AE (2019) Closed removable thread vascular anastomosis stent (Lasheen Vascular Stent). J Surg Surgical Res 5(2): 071-073.

show abstract

Biodegradation and Immunological Parameters of Polyurethane‐Based Tissue Adhesive in Arterial Microvascular Anastomoses—A Long‐Term In Vivo Study

Modabber

Winnand

Goloborodko

et al. 2022

Macromolecular Bioscience

View full text Add to dashboard Cite

In microsurgical anastomosis, non‐synthetic fibrin‐based adhesives have predominantly shown superior properties to synthetic cyanoacrylates, but they have hardly any clinical application. This study aims to investigate the local and systemic effects of synthetically produced biodegradable adhesive VIVO when used in microsurgical anastomosis. VIVO is used in two different anastomosis procedures in the common carotid artery in a rat model: VIVO in addition to a temporary catheter (VIVO TC) and VIVO with a custom‐shaped memory nitinol stent (VIVO SM). Conventionally sutured anastomoses serve as controls (C). Tissue response is assessed by in vivo fluorescence imaging and histological examination. The systemic effects of biodegradation are measured using hematologic parameters and serum levels of transaminase activity and lactate dehydrogenase. Finally, the degree of local adhesion of the different anastomotic procedures is evaluated. Fluorescence imaging shows reduced inflammatory blood flow in the VIVO TC group. Histological analysis of the anastomosed vessels also reveals significantly more inflammation in C than in the two adhesive groups. The severity of VIVO adhesions proves acceptable, and no histotoxic effects of VIVO are detected. The data demonstrate that the synthetic tissue adhesive VIVO is a reliable and—compared to sutures—tissue‐friendly adhesive for microsurgical anastomoses.

show abstract

Risk of Thromboembolus after Application of Different Tissue Glues during Microvascular Anastomosis

Abstract: The application of tissue glues in microvascular anastomosis reduces the time needed for anastomosis but was associated with a statistically significant increase in thromboembolism.

Cited by 12 publications

References 9 publications

Use of thrombin‐based haemostatic matrix in head and neck reconstructions: a potential risk factor for pulmonary embolism

Use of thrombin‐based haemostatic matrix in head and neck reconstructions: a potential risk factor for pulmonary embolism

Closed removable thread vascular anastomosis stent (Lasheen Vascular Stent)

Biodegradation and Immunological Parameters of Polyurethane‐Based Tissue Adhesive in Arterial Microvascular Anastomoses—A Long‐Term In Vivo Study

Contact Info

Product

Resources

About