Risk of thromboembolic complications from cortisone therapy

Russek, Henry I.; Zohman, Burton L.; Russek, Allen S.

doi:10.1016/0002-8703(54)90189-1

Cited by 17 publications

(3 citation statements)

References 7 publications

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“…On the other hand, no increased frequency of thromboembolic complications or obvious coagulation disorders after corticoids or ACTH were reported by other authors (13,30,31). In a discussion on the relation between corticosteroids and thrombosis, Cope (6) concluded that the question must be considered unsettled.…”

Section: Discussionmentioning

confidence: 59%

Thromboembolic Complications, Heparin Treatment and Increase in Coagulation Factors in Cushing's Syndrome

Sjöberg

Blombäck

Granberg

1976

Journal of Internal Medicine

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Seven of 19 consecutive patientswith Cushing's syndrome demonstrated thromboembolic manifestations before or after adrenaleetomy. These were successfully treated with heparin. The mean values of coagulation factors VIII (AHF) and V as well as prothrombin were increased. There was a positive correlation between the increase in factor VIII content and the severity of disease. The possibility that these changes in blood coagulation activity reflect an increased coagulability state in Cushing's syndrome is discussed. 7-752981Acta med. scand. 199

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Section: Discussionmentioning

confidence: 59%

Thromboembolic Complications, Heparin Treatment and Increase in Coagulation Factors in Cushing's Syndrome

Sjöberg

Blombäck

Granberg

1976

Journal of Internal Medicine

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“…These authors cited also previous research which stated that long term glucocorticoid treatment led to dterations in coagulation and subsequently to thromboembolism (10,LL,t2,13). Flowever, other researchers did not find an increase in the frequenry of thromboembolism after protracted ACTH or corticoid therapy (14).…”

Section: Resultsmentioning

confidence: 90%

Increased Factor VIII Associated Activities in Cushing's Syndrome: A Probable Hypercoagulable State

et al. 1982

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SummaryThirteen women and 2 men affected by Cushing’s syndrome were investigated. The following parameters were used: plasma and urinary cortisol levels, factor VIII assay (antigen, activity and von Willebrand factor) together with other coagulative assays.Samples were taken before surgery or before medical and/or radiation therapy and every 30–50 days after treatment and continued for 11 months. Cortisol and factor VIII were increased before treatment and decreased slowly after treatment to become normal in 3–4 months. Other clotting tests did not show significant changes. It seems that high plasma cortisol levels may stimulate the production of factor VIII. Patients with Cushing’s syndrome often exhibit thromboembolic complications after surgery. It is likely that the clotting abnormalities responsible for such complications is the increased factor VIII activities level.

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“…Neither has unanimity been achieved regarding the frequency of thromboembolic complications. Most investigators (Cosgriff 1951, Siegenthaler & Isler 1959, Gootman et al 1964, Levin et al 1967, Liebermann et al 1968) have found the frequency of thromboembolism to be increased after the use of such drugs, while others (McGraw et al 1952, Russek et al 1954 have found it to be unchanged. As for the fibrinolytic system, ACTH and cortisone have been found to have no effect on it in normals (Truelove 1952).…”

Section: Coagulation and Fibrinolysismentioning

confidence: 99%

Low Fibrinolytic Activity of Blood and Vein Walls in Venous Thrombosis

Isacson¹

1971

Scandinavian Journal of Haematology

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Risk of thromboembolic complications from cortisone therapy

Cited by 17 publications

References 7 publications

Thromboembolic Complications, Heparin Treatment and Increase in Coagulation Factors in Cushing's Syndrome

Thromboembolic Complications, Heparin Treatment and Increase in Coagulation Factors in Cushing's Syndrome

Increased Factor VIII Associated Activities in Cushing's Syndrome: A Probable Hypercoagulable State

Low Fibrinolytic Activity of Blood and Vein Walls in Venous Thrombosis

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