Risk of systemic lupus erythematosus in patients with idiopathic thrombocytopenic purpura: population-based cohort study

Abstract

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Correspondence on ‘Increased risk of systemic lupus erythematosus in patients with autoimmune haemolytic anaemia: a nationwide population-based cohort study’

“…5 Recently, we presented data suggesting that various shared genetic polymorphisms are associated with an increased susceptibility for both idiopathic thrombocytopenic purpura (ITP) and SLE. 6 In the same framework, the current study by Mo et al 1 poses the intriguing question concerning the putative role of a shared genetic background as regards the concurrence of AIHA and SLE. Although the genetics of SLE is very well investigated, the genetic factors involved in the development of AIHA and its underlying molecular mechanisms are still elusive.…”

Severe Thrombocytopenia as the Main Manifestation of Childhood-Onset Systemic Lupus Erythematosus

“…In this line, Zhu F-X et al performed a retrospective cohort study to provide incidence of SLE in patients with ITP and the potential relationship between them. 25 , 26 Using a nationwide population-based data to assess the risk of SLE in patients with ITP, they demonstrated that patients with ITP had 26 times higher risk of new-onset SLE compared with the control population. For this reason, a clinical follow-up of these patients with periodic assessment of ANA, anti-dsDNA antibodies and complement levels, may be necessary.…”

High risk of systemic lupus erythematosus and antiphospholipic syndrome in patients with idiopathic thrombocytopenic purpura: Genetic aspects

“…In this framework, various studies have pointed to potential genetic factors for developing both ITP and SLE or ITP and APS, thus suggesting a shared genetic predisposition in some cases. As summarized recently by Goulielmos and Zervou, 6 forty-one pathways, 27 genes and various gene polymorphisms, i.e. IL-10 -592 C/A, IL-4 VNTR, IL-17F rs763780 etc, are shared by ITP and SLE.…”