Risk of systemic allergic reactions to allergen immunotherapy in a pediatric allergy clinic in Turkey

Erdem, Semiha Bahçeci; Nacaroğlu, Hikmet Tekin; Karaman, Sait; Karkıner, Canan Şule Ünsal; Günay, İlker; Dogan, Done; Asilsoy, Suna; Altınöz, Serdar; Can, Demet

doi:10.1016/j.ijporl.2016.02.032

Cited by 4 publications

(4 citation statements)

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“…12 In a retrospective study of 1,350 immunotherapy patients; 39 (2.8%) patients had a systemic reaction and only one of them had grade 4 reaction. 17 Our rate of systemic and local side-effects was 4.7% and 9.3%, respectively. In our study, systemic reaction was seen at a level of 4.7% in 24 patients, stage 1 in 23 patients, and 1 patient with stage 2, grade 3-4 reactions were not determined.…”

Section: Discussionmentioning

confidence: 63%

“…In another study, 56.4% of patients with a systemic reaction were found to be in peak pollen season. 17 Ebstein et al 25 reported that low doses of allergen may decrease the severity of systemic reactions in the peak pollen seasons. The results of our study suggested that systemic reactions due to immunotherapy were increased in the peak pollen season in the patients with pollen sensitivity.…”

Section: Discussionmentioning

confidence: 99%

“…27 However, there are also studies that find systemic reactions more frequent and severe in the idiopathic phase. 17,20 In addition, slow dose increase in recommendations may also have affected prevalence of side-effects in line with the allergen extract. In our study, the rate of systemic reactions in dose increased period was significantly higher than in maintenance period.…”

Section: Sensitivity Of the Patient Might Have Increasedmentioning

confidence: 99%

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Safety of subcutaneous allergen immunotherapy in children: A retrospective review and bird eye to literature

et al. 2018

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Toprak-Kanık E, Yılmaz Ö, Yangın-Ergon E, Türkeli A, Yüksel H. Safety of subcutaneous allergen immunotherapy in children: A retrospective review and bird eye to literature. Turk J Pediatr 2018; 60: 684-690.Subcutaneous allergen immunotherapy (SCIT) has been shown to improve clinical course in children with asthma and allergic rhinitis (AR). Systemic and local side-effects may be seen during its administration. The purpose of this study was to evaluate risk factors associated with systemic and local side-effects in children receiving SCIT. We performed a retrospective chart review in the children who received allergen subcutaneous immunotherapy for asthma and/or allergen rhinitis. Demographic data, diagnosis, skin prick test results, presence of additional allergic diseases, the seasonal variation of adverse events in the first and third years of SCIT were recorded. A total of 508 eligible patients were included in the study. Mean age of the children was 10.9±3.2 years, and 65.4% were male. Asthma was present in 21.9% of the children, AR in 44.7%, 33.5% of them had both asthma and AR. According to the skin prick test results, sensitivity to more than one allergen was present in 45.1%, while the most common single-allergen sensitivities were to grass pollen and dermatophagoids (32.5% and 14.4%, respectively). Ratio of systemic and local side-effects was 4.7% and 9.3%, respectively. Local side-effects were more common than systemic reaction. SCIT is a safe treatment modality while using the appropriate dose and with the administration of dose-escalation protocol.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Sensitivity Of the Patient Might Have Increasedmentioning

confidence: 99%

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Safety of subcutaneous allergen immunotherapy in children: A retrospective review and bird eye to literature

et al. 2018

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“…Systemic reactions can affect many systems such as the skin, respiratory system, gastrointestinal system (GIS), and cardiovascular system. Systemic reactions can be seen as mild allergic rhinitis symptoms and may be occur even in the form of fatal reactions such as severe anaphylaxis affecting the cardiac system [ 8 ]. Systemic reactions are rare and their prevalence after injection doses varies between 1% and 0.1%.…”

Section: Highlight Key Pointsmentioning

confidence: 99%

Retrospective evaluation of adverse reactions after subcutaneous allergen-specific immunotherapy in children with house dust mite allergy

Altas¹

2023

North Clin Istanbul

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OBJECTIVE Although it is accepted as an effective and safe treatment way, side effects can be observed as a result of subcutaneous immunotherapy (SCIT). In our study, it was aimed to evaluate the local and systemic reactions in children after SCIT and the factors that may be associated with these reactions. METHODS Our study included 138 house dust mite allergic patients with asthma and/or allergic rhinitis who underwent SCIT in the Pediatric Allergy and Immunology Outpatient Clinic between November 2013 and April 2022. Sociodemographic, clinical, laboratory features, and development of adverse reactions after SCIT were analyzed from patient files. RESULTS The median age of 138 patients was 9.0 years. About 56.5% (n=78) were male, 43.5% (n=60) were female. Of the patients, 55.1% (n=76) had asthma and allergic rhinitis. A total of 7366 SCIT injections were administered to all patients in our clinic. The total number of observed adverse reaction was 118. 50.7% of the patients (n=70) experienced at least one adverse reaction after SCIT. The rate of development of adverse reactions per injection was 1.6% (local: 1.0%, large local: 0.1%, systemic: 0.5%). CONCLUSION Although serious systemic reactions and death were not observed in our patients; care should be taken in terms of the development of adverse reactions during SCIT in children.

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Systemic Allergic Reactions and Anaphylaxis Associated with Allergen Immunotherapy

Dhamija

Epstein

Bernstein

2022

Immunology and Allergy Clinics of North America

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Risk of systemic allergic reactions to allergen immunotherapy in a pediatric allergy clinic in Turkey

Cited by 4 publications

References 13 publications

Safety of subcutaneous allergen immunotherapy in children: A retrospective review and bird eye to literature

Safety of subcutaneous allergen immunotherapy in children: A retrospective review and bird eye to literature

Retrospective evaluation of adverse reactions after subcutaneous allergen-specific immunotherapy in children with house dust mite allergy

Systemic Allergic Reactions and Anaphylaxis Associated with Allergen Immunotherapy

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